JNK/JIP3 Antibody [mFluor Violet 500 SE]

Product Discontinued

JNK/JIP3 Antibody [mFluor Violet 500 SE] Summary

• Immunogen: mitogen-activated protein kinase 8 interacting protein 3. (Uniprot# Q9UPT6)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: MAPK8IP3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

mFluor(TM) is a trademark of AAT Bioquest, Inc. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for JNK/JIP3 Antibody [mFluor Violet 500 SE]

• C-jun-amino-terminal kinase interacting protein 3
• C-Jun-amino-terminal kinase-interacting protein 3
• DKFZp762N1113
• homolog of Drosophila Sunday driver 2
• JIP-3
• JIP3FLJ00027
• JNK MAP kinase scaffold protein 3
• JNK/SAPK-associated protein-1
• JNK/stress-activated protein kinase-associated protein 1
• JNK-interacting protein 3
• JSAP1
• KIAA1066SYD2
• mitogen-activated protein kinase 8 interacting protein 3
• Mitogen-activated protein kinase 8-interacting protein 3
• syd

Background

c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members, JNK2 and JNK3, have been identified. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MAPK8IP3