JNK/JIP3 Products

Antibodies
JNK/JIP3 [p Thr183, p Tyr185] ...
JNK/JIP3 [p Thr183, p Tyr185] Anti...
MAB1205
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC
Host: Rabbit Monoclonal
JNK/JIP3 [p Thr183, p Tyr185] ...
JNK/JIP3 [p Thr183, p Tyr185] Anti...
AF1205
Species: Hu, Mu, Rt
Applications: WB, Simple Western, IHC
Host: Rabbit Polyclonal
JNK/JIP3 Antibody - Pan Speci ...
JNK/JIP3 Antibody - Pan Specific
AF1387
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Rabbit Polyclonal
Proteins
JNK/JIP3 Recombinant Protein ...
JNK/JIP3 Recombinant Protein Antigen
NBP2-49593PEP
Species: Hu
Applications: AC
JNK/JIP3 Recombinant Protein ...
JNK/JIP3 Recombinant Protein Antigen
NBP2-38490PEP
Species: Hu
Applications: AC

Description

c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members, JNK2 and JNK3, have been identified. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Mouse
Product By Gene ID 23162
Alternate Names
  • JNK-interacting protein 3
  • JNK/stress-activated protein kinase-associated protein 1
  • JNK MAP kinase scaffold protein 3
  • JNK/SAPK-associated protein-1
  • JIP-3
  • homolog of Drosophila Sunday driver 2
  • Mitogen-activated protein kinase 8-interacting protein 3
  • C-Jun-amino-terminal kinase-interacting protein 3
  • syd
  • C-jun-amino-terminal kinase interacting protein 3
  • JSAP1
  • KIAA1066SYD2
  • JIP3FLJ00027
  • DKFZp762N1113
  • mitogen-activated protein kinase 8 interacting protein 3

PTMs for JNK/JIP3

Learn more about PTMs related to JNK/JIP3.

Phosphorylation
Ribosylation
Dephosphorylation

Bioinformatics Tool for JNK/JIP3

Discover related pathways, diseases and genes to JNK/JIP3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.