JNK/JIP3 Products

Description

c-Jun NH2-terminal kinases (JNKs) are distant members of the MAP kinase family. JNK1 is activated by dual phosphorylation at a Thr-Pro-Tyr motif in response to ultraviolet (UV) light, and it functions to phosphorylate c-Jun at amino terminal serine regulatory sites Ser 63 and Ser 73, resulting in transcriptional activation. Two additional JNK family members, JNK2 and JNK3, have been identified. JIP-1 (for JNK interacting protein-1) has been identified as a cytoplasmic inhibitor of JNK that retains JNK in the cytoplasm, thereby inhibiting JNK-regulated gene expression. Evidence suggests that JNK1 and JNK2 bind to JIP-1 with greater affinity than to ATF-2 and c-Jun, which are targets of the JNK signaling pathway. JIP-1 contains an amino terminal JNK binding domain and a carboxy terminal SH3 domain. ATF-2 and c-Jun also contain the JNK binding domain and are thought to compete with JIP-1 for JNK binding. Multiple splice variants of JIP-1, including JIP-1b, JIP-1c (also designated islet-brain 1 or IB-1), JIP-2a, JIP-2b and JIP-3, have been identified in brain.

Bioinformatics

Entrez	23162 Human 30957 Mouse
Uniprot	NP_055948 Human Q9ESN9 Mouse Q9UPT6 Human
Product By Gene ID	23162
Alternate Names	C-jun-amino-terminal kinase interacting protein 3 C-Jun-amino-terminal kinase-interacting protein 3 DKFZp762N1113 homolog of Drosophila Sunday driver 2 JIP-3 JIP3FLJ00027 JNK MAP kinase scaffold protein 3 JNK/SAPK-associated protein-1 JNK/stress-activated protein kinase-associated protein 1 JNK-interacting protein 3 JSAP1 KIAA1066SYD2 mitogen-activated protein kinase 8 interacting protein 3 Mitogen-activated protein kinase 8-interacting protein 3 syd