Jarid1A Antibody (1102542) [Alexa Fluor® 488]

• Reactivity: Hu
• Clone: 1102542
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

Jarid1A Antibody (1102542) [Alexa Fluor® 488] Summary

• Immunogen: E. coli-derived recombinant human Jarid1A/KDM5A
  Lys127-Ser287
  Accession # P29375
• Specificity: Detects recombinant human Jarid1A/KDM5a protein in Direct ELISA.
• Source: N/A
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Jarid1A Antibody (1102542) [Alexa Fluor® 488]

• EC 1.14.11
• EC 1.14.11.-
• EC 1.14.11.67
• Histone demethylase JARID1A
• Jarid1A
• JARID1AJumonji, AT rich interactive domain 1A (RBP2-like)
• Jumonji, AT rich interactive domain 1A (RBBP2-like)
• Jumonji/ARID domain-containing protein 1A
• KDM5A
• lysine (K)-specific demethylase 5A
• RBBP2
• RBBP-2
• RBBP2lysine-specific demethylase 5A
• RBP2
• RBP2retinoblastoma binding protein 2
• Retinoblastoma-binding protein 2jumonji, AT rich interactive domain 1A

Background

Jarid1A (also known as KDM5A) is a protein of approximately 175kDa that belongs to the Jumonji/ARID1 (JARID) protein family. It functions primarily as a lysine demethylase, involved in the regulation of histone H3 lysine 4 (H3K4) demethylation, thereby playing a crucial role in chromatin remodeling and epigenetic regulation. Jarid1A is implicated in multiple biological processes, including cell cycle progression, differentiation, and development. Dysregulation of Jarid1A is associated with various pathologies, particularly its overexpression in several types of cancer, where it contributes to tumorigenesis, cancer cell proliferation, and metastasis. It is also linked to altered gene expression profiles in neurological disorders. The role of Jarid1A in transcriptional regulation highlights its potential as a therapeutic target and biomarker for cancer and other diseases involving epigenetic dysregulation.

1. Harmeyer KM, Facompre ND, Herlyn M, Basu D. JARID1 Histone Demethylases: Emerging Targets in Cancer. Trends Cancer. 2017 Oct;3(10):713-725. doi: 10.1016/j.trecan.2017.08.004. Epub 2017 Sep 12. PMID: 28958389; PMCID: PMC5679451. 
2. Yang GJ, Zhu MH, Lu XJ, Liu YJ, Lu JF, Leung CH, Ma DL, Chen J. The emerging role of KDM5A in human cancer. J Hematol Oncol. 2021 Feb 17;14(1):30. doi: 10.1186/s13045-021-01041-1. PMID: 33596982; PMCID: PMC7888121.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • P29375(Mouse)