Immunohistochemistry-Paraffin: Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Antibody [NB100-97821] - Section of human prostate carcinoma. Antibody: Rabbit anti-JARID1B antibody used at 1:500 (2ug/ml). Secondary: ...read more
Immunoprecipitation: Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Antibody [NB100-97821] - Detection of human JARID1B by western blot of immunoprecipitates. Samples: Whole cell lysate (1.0 mg per IP reaction; 20% of ...read more
Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections. Flow reactivity reported in (PMID: 30721788). Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B antibody validated for IHC-P from a verified customer review.
Alternate Names for Lysine (K)-specific Demethylase 5B/KDM5B/JARID1B Antibody
Jumonji, AT rich interactive domain 1B (RBP2-like)
jumonji, AT rich interactive domain 1B
Lysine (K)specific Demethylase 5B
Lysine (K)-specific Demethylase 5B
Retinoblastoma-binding protein 2 homolog 1
JARID1B (Jumonji AT-rich interactive domain 1B) is a member of the JARID 1 family of proteins that catalyze the demethylation of histones on lysine. The Jarid 1 family members include JARID1A, JARID1B, JARID1C and JARID1D. The members of this family possess a Jumonji C (JmjC) and Jumonji N (JmjN) domain as well as one ARID (AT-rich interactive domain) and three PHD-type zinc fingers. As histone demethylases, JARID 1 proteins function as transcriptional repressors. JARID1B expression is largely restricted to testis and may play a critical role in tumorigenesis as it has been found to be upregulated in prostate and breast cancer. Alternative names for JARID1B include retinoblastoma-binding protein 2 homolog 1, RBP2-H1, cancer/testis antigen 31, CT31, PLU-1, PUT1, and KDM5B.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Chauvistre H, Daignault SM, Shannan B, Ju RJ The Janus-faced role of KDM5B heterogeneity in melanoma: differentiation as a situational driver of both growth arrest and drug-resistance bioRxiv Jan 1 2020 (ICC/IF, Human)
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