ITIH2 Antibody (2688A) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: IHC
• Clone: 2688A
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor 700

ITIH2 Antibody (2688A) [Alexa Fluor® 700] Summary

• Additional Information: Recombinant Monoclonal Antibody.
• Immunogen: Spodoptera frugiperda Sf 9 (baculovirus)-derived human ITIH2
  Ser55-Asp702
  Accession # P19823
• Specificity: Detects human ITIH2 in direct ELISAs.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for ITIH2 Antibody (2688A) [Alexa Fluor® 700]

• H2P
• IGHEP2
• Inter-Alpha (Globulin) Inhibitor H2
• inter-alpha (globulin) inhibitor, H2 polypeptide
• Inter-alpha-inhibitor heavy chain 2
• Inter-alpha-trypsin inhibitor complex component II
• inter-alpha-trypsin inhibitor heavy chain H2
• Intin2
• ITI Heavy Chain H2
• ITIH2
• ITI-H2
• ITI-HC2
• Serum-derived hyaluronan-associated protein
• SHAP

Background

The ITIs are a family of plasma protease inhibitors contributing to extracellular matrix stabilization by covalent linkage to hyaluronan.  ITIH2 is a binding protein between hyaluronan and other matrix proteins.  It regulates the localization, synthesis and degradation of hyaluronan.  ITIH molecules are shown to play a role in carcinogenesis and inflammation.  ITIH genes are downregulated in multiple human solid tumors.  This downregulation contributes to initiation and/or progression of malignancy. 

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.