IRS1 [p Tyr1179] Antibody

Western Blot: IRS1 [p Tyr1179] Antibody [NB100-74450] - Lysate from insulin-treated 3T3 L1 cells.

• Reactivity: Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated

IRS1 [p Tyr1179] Antibody Summary

• Description: Novus Biologicals Rabbit IRS1 [p Tyr1179] Antibody (NB100-74450) is a polyclonal antibody validated for use in WB. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Synthetic phosphopeptide corresponding to residues L(1173) E N G L N (pY) I D L D L V K(1186) of human IRS-1.
• Modification: p Tyr1179
• Localization: Cytoplasmic
• Specificity: Detects phosphorylated IRS-1 (Tyr1173) in mouse cells.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: IRS1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:100 - 1:2000

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS with 1 mg/ml BSA
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for IRS1 [p Tyr1179] Antibody

• HIRS-1
• insulin receptor substrate 1
• IRS1
• IRS-1

Background

Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS-1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS-1 degradation pathways are not well understood. IRS-1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS-1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS-1, 2, 3 and 4, with IRS-1 being widely expressed.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IRS1
• Entrez:
  • 16367(Mouse)