IRS1 [p Tyr1179] Antibody

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Western Blot: IRS1 [p Tyr1179] Antibody [NB100-74450] - Lysate from insulin-treated 3T3 L1 cells.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated

Order Details

IRS1 [p Tyr1179] Antibody Summary

Immunogen
Synthetic phosphopeptide corresponding to residues L(1173) E N G L N (pY) I D L D L V K(1186) of human IRS-1.
Modification
p Tyr1179
Localization
Cytoplasmic
Specificity
Detects phosphorylated IRS-1 (Tyr1173) in mouse cells.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
IRS1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100 - 1:2000

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS with 1mg/ml BSA
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for IRS1 [p Tyr1179] Antibody

  • HIRS-1
  • insulin receptor substrate 1
  • IRS1
  • IRS-1

Background

Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS-1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS-1 degradation pathways are not well understood. IRS-1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS-1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS-1, 2, 3 and 4, with IRS-1 being widely expressed.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

FAQs for IRS1 Antibody (NB100-74450) (0)

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol IRS1
Entrez
Uniprot

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