IRS1 Products

Antibodies
IRS1 Antibody
IRS1 Antibody
AF3978
Species: Hu, Mu, Rt
Applications: WB, IHC
Host: Goat Polyclonal
IRS1 Antibody (3G10)
IRS1 Antibody (3G10)
Species: Hu
Applications: WB, IHC, IHC-P
Host: Mouse Monoclonal
IRS1 Antibody
IRS1 Antibody
NB100-82001
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
IRS1 Overexpression Lysate (D ...
IRS1 Overexpression Lysate (Denatu...
H00003667-T01
Species: Hu
Applications: WB
Proteins
IRS1 Blocking Peptide
IRS1 Blocking Peptide
NBP1-77216PEP
Species: Hu
Applications: AC

Description

Insulin receptor substrates (IRS), the major intracellular substrates of the insulin receptor (IR), are adaptor proteins that transduce signals from the IR to downstream effectors that are important for the biological effect of insulin (1-2). After insulin stimulation, IRS proteins are rapidly phosphorylated on multiple tyrosine residues. Once phosphorylated, IRS proteins bind and activate Grb-2, SHP2 and the PI3-K p85 subunit (2-3). IRS-1 functions as one of the key regulators of IR and the insulin-like growth factor-1 receptor. Disruption of IRS-1 causes growth retardation and insulin resistance associated with hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation (4-5)

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 3667
Alternate Names
  • IRS-1
  • HIRS-1
  • insulin receptor substrate 1

Research Areas for IRS1

Find related products by research area and learn more about each of the different research areas below.

Autophagy
Cancer
Diabetes Research
Lipid and Metabolism
mTOR Pathway
Nutrient Sensing in the Brain
Phospho-Specific
Signal Transduction

Bioinformatics Tool for IRS1

Discover related pathways, diseases and genes to IRS1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related IRS1 Blog Posts

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