Integrin alpha 2/CD49b Antibody (HAS-4) - BSA Free

• Reactivity: Hu
• Applications: Flow, ICC/IF, IHC, IP, CyTOF-ready
• Clone: HAS-4
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

Integrin alpha 2/CD49b Antibody (HAS-4) - BSA Free Summary

• Immunogen: Human keratinocytes
• Localization: Plasma membrane
• Marker: Plasma Membrane Marker
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: ITGA2
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Flow Cytometry 1:10 - 1:1000
  • Immunocytochemistry/ Immunofluorescence 1:10 - 1:500
  • Immunohistochemistry 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
• Application Notes: Co-precipitates integrin alpha 2 beta 1 from keratinocytes and inhibits HGF-induced branching morphogenesis and motility of human mammary epithelial HB2 cells in collagen.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Protein A purified

Alternate Names for Integrin alpha 2/CD49b Antibody (HAS-4) - BSA Free

• alpha-2 subunit
• CD49b antigen
• CD49b
• Integrin alpha 2
• integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
• ITGA2
• VLA 2
• VLA-2 alpha

Background

Integrins are heterodimeric cell surface receptors composed of alpha and beta subunits, which mediate cell-cell and cell-extracellular matrix attachments. They are responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Aberrant integrin expression has been found in many epithelial tumours. Changes in integrin expression have been shown to be important for the growth and early metastatic capacity of melanoma cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Integrin alpha 2/CD49b Antibody (NB100-2608)(1)

Publication using NB100-2608

• Kishimoto N, MomotaY, Hashimoto Y et al. Self-assembling Peptide RADA16 as a Scaffold in Bone Tissue Engineering Using Dedifferentiated Fat Cells. Journal of Oral Tissue Engineering;8(3):151-161. 2011-01-01

Bioinformatics

• Gene Symbol: ITGA2
• Entrez:
  • 3673(Human)