Western Blot: Importin alpha 2/KPNA2 Antibody [NBP1-31098] - A: HeLa S3 B: Hep G2 C: MOLT4 10% SDS PAGE; antibody diluted at 1:500
Immunocytochemistry/ Immunofluorescence: Importin alpha 2/KPNA2 Antibody [NBP1-31098] - HeLa cells were fixed in ice-cold MeOH for 5 min. Green: karyopherin alpha 2 protein stained by karyopherin alpha 2 antibody [C3], ...read more
Immunohistochemistry-Paraffin: Importin alpha 2/KPNA2 Antibody [NBP1-31098] - Paraffin-embedded human lung adenocarcinoma. karyopherin alpha 2 antibody [C3], C-term diluted at 1:250.
Immunocytochemistry/ Immunofluorescence: Importin alpha 2/KPNA2 Antibody [NBP1-31098] - Analysis of HeLa, using KPNA2 antibody at 1:200 dilution.
Immunocytochemistry/ Immunofluorescence: Importin alpha 2/KPNA2 Antibody [NBP1-31098] - Sample: HeLa cells were fixed in iced-cold MeOH for 5 min. Green: karyopherin alpha 2 protein stained by karyopherin alpha 2 ...read more
58 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
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The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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