IL-20 R beta/FNDC6 Antibody [Biotin]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Biotin
• Concentration: LYOPH

IL-20 R beta/FNDC6 Antibody [Biotin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human IL-20 R beta
  Asp30-Ala230
  Accession # Q6UXL0
• Specificity: Detects human IL-20 R beta in Western blots. In Western blots, less than 5% cross-reactivity with recombinant human (rh) IL-20 R alpha , rhIL-10 R beta , rhIFN-gamma R1, and rhIFN-gamma R2 is observed.
• Source: N/A
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: IL20RB
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.1 ug/mL
• Readout System:
  • Streptavidin Native Protein NBP2-29367
  • Streptavidin Native Protein NBP2-29370
  • Streptavidin Native Protein NBP2-29371

Packaging, Storage & Formulations

• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
• Buffer: Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
• Preservative: No Preservative
• Concentration: LYOPH
• Reconstitution Instructions: Reconstitute at 0.2 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-20 R beta/FNDC6 Antibody [Biotin]

• FNDC6
• DIRS1
• FNDC6
• IL-20 R beta
• IL20R beta
• IL-20R2
• IL20RB interleukin 20 receptor beta
• IL20RB
• IL-20Rb
• MGC34923

Background

IL-20 receptor beta (IL-20 R beta ), also known as IL-20 R2, is a transmembrane glycoprotein in the class II cytokine receptor family. These receptors are characterized by tandem fibronectin type III domains in their extracellular region and the lack of a WSXWS motif (1). Class II cytokine receptors form heterodimeric signaling receptor complexes that mediate class II cytokine signals. Subunits of the different receptor complexes are shared and serve multiple functions (1). Human IL-20 R beta consists of a 204 aa extracellular domain (ECD) with two fibronectin type III domains, a 21 aa transmembrane segment, and a 57 aa cytoplasmic domain (2). Within the ECD, human IL-20 R beta shares 81% aa sequence identity with mouse IL-20 R beta . It shares 15%‑28% aa sequence identity with the human class II cytokine receptors IFN-alpha R1, IFN-alpha R2, IFN-gamma R1, IFN-gamma R2, IL-10 R alpha , IL-10 R beta , IL-20 R alpha , IL-22BP, IL-22 R alpha , IL-28 R, and tissue factor. Strong IL-20 R beta expression is normally restricted to skin and testis (3). IL-20 R beta is also expressed in psoriatic skin, rheumatoid arthritis synovial membranes, and hepatocytes of LPS-treated mice, and it contributes to the local inflammatory reaction (3‑6). IL-20 R beta heterodimerizes with IL-20 R alpha to form the receptor complex that mediates IL-19, IL-20 and IL-24 signals (3, 7‑10). It also heterodimerizes with IL-22 R to form the functional receptor complex for IL-20 and IL-24 (7‑9). Binding of these IL-10 family class II cytokines to their receptors induces activation of the JAK-STAT signal transduction pathway.

1. Langer, J.A. et al. (2004) Cytokine Growth Factor Rev. 15:33.
2. SwissProt # Q6UXL0.
3. Blumberg, H. et al. (2001) Cell 104:9.
4. Hsu, Y.-H. et al. (2006) Arthritis Rheum. 54:2722.
5. Wegenka, U.M. et al. (2007) J. Hepatol. 46:257.
6. Chan, J.R. et al. (2006) J. Exp. Med. 203:2577.
7. Parrish-Novak, J. et al. (2002) J. Biol. Chem. 277:47517.
8. Dumoutier, L. et al. (2001) J. Immunol. 167:3545.
9. Wang, M., et al. (2002) J. Biol. Chem. 277:7341.
10. Pletnev, S. et al. (2003) Biochemistry 42:12617.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IL-20 R beta/FNDC6 Antibody (BAF1788)(3)

Publications using BAF1788

• JR Dayton, Y Yuan, LP Pacumio, BG Dorflinger, SC Yoo, MJ Olson, SI Hernández-, MM McMahon, L Cruz-Oreng Expression of IL-20 Receptor Subunit beta Is Linked to EAE Neuropathology and CNS Neuroinflammation Frontiers in Cellular Neuroscience, 2021-09-07;15(0):683687. 2021-09-07 [PMID: 34557075] (ICC, IHC, Human)
• Kate E. Keller, Yong-Feng Yang, Ying Ying Sun, Renee Sykes, Natalie Donna Gaudette, John R. Samples et al. Interleukin-20 Receptor Expression in the Trabecular Meshwork and Its Implication in Glaucoma Journal of Ocular Pharmacology and Therapeutics 2014-03-01 [PMID: 24455976]
• Maarof G, Bouchet-Delbos L, Gary-Gouy H, Durand-Gasselin I, Krzysiek R, Dalloul A Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells. Blood, 2009-11-24;115(9):1718-26. 2009-11-24 [PMID: 19965640] (Flow Cytometry, Human)

Bioinformatics

• Gene Symbol: IL20RB
• Uniprot:
  • Q6UXL0()