IL-17RD/SEF Antibody (400210) [Unconjugated]


IL‑17 RD/SEF was detected in perfusion fixed frozen sections of mouse liver using 25 µg/mL Mouse IL‑17 RD/SEF Monoclonal Antibody (Catalog # MAB2276) overnight at 4 °C. Tissue more
IL‑17 RD/SEF was detected in perfusion fixed frozen sections of mouse thymus using Mouse IL‑17 RD/SEF Monoclonal Antibody (Catalog # MAB2276) at 25 µg/mL overnight at 4 °C. more
HEK293 human cell line transfected with mouse IL-17 RD/SEF was stained with Rat Anti-MouseIL-17 RD/SEF Monoclonal Antibody (Catalog # MAB2276, filled histogram) or isotype control antibody (Catalog # MAB006, open more
IL‑17 RD/SEF was detected in immersion fixed frozen sections of mouse lung using Mouse IL‑17 RD/SEF Monoclonal Antibody (Catalog # MAB2276) at 25 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Rat more

Product Details

Reactivity MuSpecies Glossary
Applications Flow, IHC, CyTOF-ready

Order Details

IL-17RD/SEF Antibody (400210) [Unconjugated] Summary

Mouse myeloma cell line NS0-derived recombinant mouse IL-17 RD/SEF
Accession # Q8JZL1
Detects mouse IL‑17 RD/SEF in direct ELISAs.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Flow Cytometry 0.25 ug/10^6 cells
  • Immunohistochemistry 8-25 ug/mL
  • CyTOF-ready
Read Publication using
MAB2276 in the following applications:

Packaging, Storage & Formulations

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
No Preservative
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IL-17RD/SEF Antibody (400210) [Unconjugated]

  • FLJ35755
  • IL-17 RD
  • IL17RD
  • IL-17RD
  • IL-17RDIL-17 receptor D
  • IL17Rhom
  • IL17RLM
  • IL17RLMDKFZp434N1928
  • interleukin 17 receptor D
  • interleukin-17 receptor D
  • Interleukin-17 receptor-like protein
  • MGC133309
  • Sef homolog
  • SEF
  • SEFhSef


Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane (1‑5). The gene for this protein belongs to a synexpression group originally identified in zebrafish and SEF is expressed along with FGF-3, -8, sprouty-2 (SPRY2) and SPRY4 (6, 7). Due to the presence of an alternate start site, there is one transcript that potentially gives rise to two isoforms. The first is a full-length long form and the second an N-terminally truncated form (2, 5). The significance and expression pattern of the short form are uncertain. The membrane‑bound long form of mouse IL-17 RD is synthesized as a 738 amino acid (aa) precursor protein with a putative 27 aa signal peptide, a 272 aa extracellular domain, a 20 aa transmembrane segment and a 419 aa cytoplastic domain (5). The extracellular domain contains one Ig-like domain and a fibronectin type III motif. The cytoplasmic domain shares homology with the intracellular domains of IL‑17 receptor family members and shows one TIR (Toll/IL-1 Receptor) domain and a putative TRAF6-binding motif (2). Natural IL-17 RD has been shown to form homomultimeric complexes (3). The full-length IL-17 RD isoform is expressed in most adult tissues and during embryonic development (3, 5). Functionally, IL-17 RD has been shown to be an inhibitor of FGF signaling. The molecule’s extracellular domain does not seem to be involved. There is an interaction between the intracellular domains of FGF R1/2 and IL-17 RD that blocks ERK dissociation from MEK, thereby interfering with downstream ERK activation of nuclear Elk-1 (8). IL-17 RD has also been reported to interact with TAK1 and induce JNK activation and apoptosis (9). Ligands that interact with the extracellular domain of IL-17 RD have not been identified.

  1. Furthauer, M. et al. (2002) Nat. Cell Biol. 4:170.
  2. Xiong, S. et al. (2003) J. Biol. Chem. 278:50273.
  3. Yang, R-B. et al. (2003) J. Biol. Chem. 278:33232.
  4. Preger, E. et al. (2003) Proc. Natl. Acad. Sci. USA 101:1229.
  5. Lin, W. et al. (2002) Mech. Dev. 113:163.
  6. Tsang, M. et al. (2002) Nat. Cell Biol. 4:165.
  7. Kovalenko, D. et al. (2003) J. Biol. Chem. 278:14087.
  8. Torii, S. et al. (2004) Dev. Cell 7:33.
  9. Yang, X. et al. (2004) J. Biol. Chem. 279:38099.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for IL-17RD/SEF Antibody (MAB2276)(1)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC-Fr.

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Secondary Antibodies


Isotype Controls

Other Available Formats

Alexa Fluor 488 FAB2276G
Alexa Fluor 594 FAB2276T
Alexa Fluor 647 FAB2276R
Alexa Fluor 700 FAB2276N
Alexa Fluor 750 FAB2276S

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Gene Symbol IL17RD