IL-12 R beta 1 Antibody

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Western Blot: IL-12 R beta 1 Antibody [NBP1-49875] - Analysis of IL12RB1 in Peripharal Blood Lymphocytes lysate (35ug protein in RIPA buffer) using NBP1-49875 at 0.3 ug/ml. Primary incubation was 1 hour. Detected by ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

IL-12 R beta 1 Antibody Summary

Immunogen
Peptide with sequence C-HVSVKNHSLDSVS corresponding to internal region according to NP_005526.1.
Epitope
HVSVKNHSLDSVS - Internal region
Specificity
This antibody is expected to recognize isoform 1 (NP_005526.1) only.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
IL12RB1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.3 - 1 ug/ml
  • Peptide ELISA Detection limit 1:8000
Application Notes
WB: Approx. 100 kDa band observed in human peripheral blood mononucleocytes lysates (calculated MW of 73.1 kDa band according to NP_005526.1). The observed molecular weight corresponds to the glycosylated form.
Publications
Read Publication using NBP1-49875.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for IL-12 R beta 1 Antibody

  • CD212 antigen
  • CD212
  • IL-12 R beta 1
  • IL-12 receptor beta component
  • IL-12 receptor subunit beta-1
  • IL12R beta 1
  • IL-12R subunit beta-1
  • IL12R
  • IL12RB
  • IL12RB1
  • IL-12Rb1
  • IL-12R-BETA1
  • IL-12R-beta-1
  • interleukin 12 receptor, beta 1
  • interleukin-12 receptor beta-1 chain
  • interleukin-12 receptor subunit beta-1
  • MGC34454

Background

The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol IL12RB1
Entrez
Uniprot