IKK alpha Antibody [Alexa Fluor® 350]

• Reactivity: Hu, Mu, Rt
• Applications: WB, ICC/IF
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 350

IKK alpha Antibody [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human IKKα
  Gly375-Glu745
  Accession # O15111
• Specificity: Detects human, mouse, and rat IKK alpha . Does not cross-react with recombinant human (rh) IKK beta , rhIKK gamma , or rhIKK epsilon .
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 degreesC as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IKK alpha Antibody [Alexa Fluor® 350]

• CHUK
• conserved helix-loop-helix ubiquitous kinaseIKBKA
• EC 2.7.11
• EC 2.7.11.10
• I-kappa-B kinase 1
• I-kappa-B kinase alpha
• IkappaB kinase
• IkBKA
• IkBKalpha
• IKK alpha
• IKK1
• IKK1I-kappa-B kinase-alpha
• IKK-A
• IKKAIkB kinase alpha subunit
• IKK-alphainhibitor of nuclear factor kappa-B kinase subunit alpha
• NFKBIKA
• NFKBIKAIKK-a kinase
• Nuclear factor NFkappaB inhibitor kinase alpha
• Nuclear factor NF-kappa-B inhibitor kinase alpha
• TCF16
• TCF-16
• Transcription factor 16

Background

I kappa B kinase alpha (IKK alpha ) is also known as IKBKA, CHUK, and IKK1. The classical active IKK complex, composed of IKK alpha , IKK beta , and two forms of processed IKK gamma , phosphorylates and inactivates I kappa B, resulting in the release and nuclear translocation of active NF-kappa B. IKK alpha contains kinase, leucine zipper, and helix-loop-helix domains, and heterodimerizes with IKK beta . NF-kappa B-inducing kinase (NIK) phosphorylates and activates IKK alpha .

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Uniprot:
  • O15111()