IKK alpha Products

IKK alpha Antibody
IKK alpha Antibody
Species: Hu, Mu, Ad, Canine, Equine, Guinea Pig, Primate, Rabbit, Rat, Bat, Chinese Hamster
Applications: WB, IHC, IHC-P, IP, PLA
Host: Rabbit Polyclonal
IKK alpha Antibody [Unconjuga ...
IKK alpha Antibody [Unconjugated]
Species: Hu, Mu, Rt
Applications: WB, ICC
Host: Sheep Polyclonal
IKK alpha Overexpression Lysa ...
IKK alpha Overexpression Lysate (N...
Applications: WB
IKK alpha Partial Recombinant ...
IKK alpha Partial Recombinant Protein
Species: Hu
Applications: WB, ELISA, PA
IKK alpha Recombinant Protein ...
IKK alpha Recombinant Protein Antigen
Species: Hu
Applications: B/N, Ctrl
IKK alpha Peptide
IKK alpha Peptide
Species: Hu
Applications: B/N
IKK alpha RNAi
IKK alpha RNAi
Species: Hu


IKK-alpha (I-Kappa-B kinase-alpha) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP (1-2). Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. Activation of NFKB by TNF requires phosphorylation of IKK-alpha at threonine 23 and serine 176 by AKT1 and NIK respectively (3). It has been demonstrated that IKK-alpha can accumulate in the nucleus after cytokine exposure (4). In the nucleus IKK-alpha interacts with CREB-binding protein in conjunction with RELA to be recruited to the NF-kappa-B-responsive promoters in order to mediate the cytokine-induced phosphorylation and subsequent acetylation of specific residues in histone H3 (5).


Entrez Human
Uniprot Human
Product By Gene ID 1147
Alternate Names
  • EC 2.7.11
  • EC
  • Nuclear factor NF-kappa-B inhibitor kinase alpha
  • I-kappa-B kinase 1
  • IkappaB kinase
  • TCF16
  • I-kappa-B kinase alpha
  • TCF-16
  • IKK-A
  • Transcription factor 16
  • Nuclear factor NFkappaB inhibitor kinase alpha
  • IkBKA
  • IKK-alphainhibitor of nuclear factor kappa-B kinase subunit alpha
  • NFKBIKAIKK-a kinase
  • IKKAIkB kinase alpha subunit
  • IKK1I-kappa-B kinase-alpha
  • conserved helix-loop-helix ubiquitous kinaseIKBKA

Research Areas for IKK alpha

Find related products by research area and learn more about each of the different research areas below.

DNA Repair
DNA replication, Transcription, Translation and Splicing
Innate Immunity
mTOR Pathway
Protein Kinase
Signal Transduction

Bioinformatics Tool for IKK alpha

Discover related pathways, diseases and genes to IKK alpha. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.

Related IKK alpha Blog Posts

Check out the latest blog posts on IKK alpha.
IKK alpha says "no" to NFk beta
The nuclear factor kappa B (NFkB) is a ubiquitous transcription factor essential for the activation of immune and inflammatory responses. NFkB activity is inhibited when it is associated with IkB proteins in the cell cytoplasm. IkB proteins are phosph...    Read more.
Regulating Immune Response Pathways with IKK beta
IKK beta, also known as IKK2, activates the NFkB complex by phosphorylating the NFkB inhibitor, IkBa. Several transcript variants, some protein-coding and some not, have been found for IKKB. The Nuclear Factor-kappa B (NF-kB) family of transcription f...    Read more.
IKK alpha: Roles in Development, B-cell Survival and ESC Differentiation
Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK1 alpha) is a serine/threonine kinase that forms a complex with IKK beta and NEMO. It plays an essential role in embryonic skin development. Mice with low levels of IKKa show an increase in...    Read more.
Read more IKK alpha related blogs.