Species: Hu, Mu, Rt, Pm
Applications: WB, Simple Western, ChIP, Flow, Flow-IC, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF
Host: Sheep Polyclonal
Species: Hu, Rt
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
Species: Hu
Applications: AC
Description
IKK-alpha (I-Kappa-B kinase-alpha) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP (1-2). Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. Activation of NFKB by TNF requires phosphorylation of IKK-alpha at threonine 23 and serine 176 by AKT1 and NIK respectively (3). It has been demonstrated that IKK-alpha can accumulate in the nucleus after cytokine exposure (4). In the nucleus IKK-alpha interacts with CREB-binding protein in conjunction with RELA to be recruited to the NF-kappa-B-responsive promoters in order to mediate the cytokine-induced phosphorylation and subsequent acetylation of specific residues in histone H3 (5).
Bioinformatics
| Entrez |
Human
Mouse
Rat
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
1147 |
| Alternate Names |
- conserved helix-loop-helix ubiquitous kinaseIKBKA
- EC 2.7.11
- EC 2.7.11.10
- I-kappa-B kinase 1
- I-kappa-B kinase alpha
- IkappaB kinase
- IkBKA
- IKK1I-kappa-B kinase-alpha
- IKK-A
- IKKAIkB kinase alpha subunit
- IKK-alphainhibitor of nuclear factor kappa-B kinase subunit alpha
- NFKBIKAIKK-a kinase
- Nuclear factor NFkappaB inhibitor kinase alpha
- Nuclear factor NF-kappa-B inhibitor kinase alpha
- TCF16
- TCF-16
- Transcription factor 16
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Bioinformatics Tool for IKK alpha
Discover related pathways, diseases and genes to IKK alpha. Need help? Read the
Bioinformatics Tool Guide for instructions on using this tool.
Related IKK alpha Blog Posts
Check out the latest blog posts on IKK alpha.
IKK alpha: Roles in Development, B-cell Survival and ESC Differentiation
Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK1 alpha) is a serine/threonine kinase that forms a complex with IKK beta and NEMO. It plays an essential role in embryonic skin development. Mice with low levels of IKKa show an increase in ... Read more.
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Regulating Immune Response Pathways with IKK beta
IKK beta, also known as IKK2, activates the NFkB complex by phosphorylating the NFkB inhibitor, IkBa. Several transcript variants, some protein-coding and some not, have been found for IKKB. The Nuclear Factor-kappa B (NF-kB) family of transcription f... Read more.
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IKK alpha says "no" to NFk beta
The nuclear factor kappa B (NFkB) is a ubiquitous transcription factor essential for the activation of immune and inflammatory responses. NFkB activity is inhibited when it is associated with IkB proteins in the cell cytoplasm. IkB proteins are phosph... Read more.
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Read more IKK alpha related blogs.
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![Western Blot IKK alpha Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IKK_alpha_AF3768_Western_Blot_5332.jpg)
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![Immunocytochemistry IKK alpha Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/IKK_alpha_AF3768_Immunocytochemistry__Immunofluorescence_20285.jpg)
