IKK alpha Products

Antibodies
IKK alpha Antibody
IKK alpha Antibody
NBP1-06527
Species: Hu, Mu, Ad, Canine, Equine, Guinea Pig, Primate, Rabbit, Rat, Bat, Chinese Hamster
Applications: WB, IHC, IHC-P, IP, PLA
Host: Rabbit Polyclonal
IKK alpha Antibody [Unconjuga ...
IKK alpha Antibody [Unconjugated]
AF3768
Species: Hu, Mu, Rt
Applications: WB, ICC
Host: Sheep Polyclonal
Lysates
IKK alpha Overexpression Lysa ...
IKK alpha Overexpression Lysate (N...
NBP2-04194
Applications: WB
Proteins
IKK alpha Partial Recombinant ...
IKK alpha Partial Recombinant Protein
H00001147-Q01
Species: Hu
Applications: WB, ELISA, PA
IKK alpha Recombinant Protein ...
IKK alpha Recombinant Protein Antigen
NBP1-89634PEP
Species: Hu
Applications: AC
IKK alpha Peptide
IKK alpha Peptide
NBP1-76974PEP
Species: Hu
Applications: AC
RNAi
IKK alpha RNAi
IKK alpha RNAi
H00001147-R02
Species: Hu

Description

IKK-alpha (I-Kappa-B kinase-alpha) is a member of the IKK complex which is composed of IKK-alpha, IKK-beta, IKK-gamma and IKAP (1-2). Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. Activation of NFKB by TNF requires phosphorylation of IKK-alpha at threonine 23 and serine 176 by AKT1 and NIK respectively (3). It has been demonstrated that IKK-alpha can accumulate in the nucleus after cytokine exposure (4). In the nucleus IKK-alpha interacts with CREB-binding protein in conjunction with RELA to be recruited to the NF-kappa-B-responsive promoters in order to mediate the cytokine-induced phosphorylation and subsequent acetylation of specific residues in histone H3 (5).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 1147
Alternate Names
  • EC 2.7.11
  • EC 2.7.11.10
  • Nuclear factor NF-kappa-B inhibitor kinase alpha
  • I-kappa-B kinase 1
  • IkappaB kinase
  • TCF16
  • I-kappa-B kinase alpha
  • TCF-16
  • IKK-A
  • Transcription factor 16
  • Nuclear factor NFkappaB inhibitor kinase alpha
  • IkBKA
  • IKK-alphainhibitor of nuclear factor kappa-B kinase subunit alpha
  • NFKBIKAIKK-a kinase
  • IKKAIkB kinase alpha subunit
  • IKK1I-kappa-B kinase-alpha
  • conserved helix-loop-helix ubiquitous kinaseIKBKA

Research Areas for IKK alpha

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
DNA replication, Transcription, Translation and Splicing
Immunology
Innate Immunity
mTOR Pathway
Phospho-Specific
Protein Kinase
Signal Transduction

Bioinformatics Tool for IKK alpha

Discover related pathways, diseases and genes to IKK alpha. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related IKK alpha Blog Posts

Check out the latest blog posts on IKK alpha.
IKK alpha says "no" to NFk beta
The nuclear factor kappa B (NFkB) is a ubiquitous transcription factor essential for the activation of immune and inflammatory responses. NFkB activity is inhibited when it is associated with IkB proteins in the cell cytoplasm. IkB proteins are phosph...    Read more.
Regulating Immune Response Pathways with IKK beta
IKK beta, also known as IKK2, activates the NFkB complex by phosphorylating the NFkB inhibitor, IkBa. Several transcript variants, some protein-coding and some not, have been found for IKKB. The Nuclear Factor-kappa B (NF-kB) family of transcription f...    Read more.
IKK alpha: Roles in Development, B-cell Survival and ESC Differentiation
Inhibitor of nuclear factor kappa-B kinase subunit alpha (IKK1 alpha) is a serine/threonine kinase that forms a complex with IKK beta and NEMO. It plays an essential role in embryonic skin development. Mice with low levels of IKKa show an increase in...    Read more.
Read more IKK alpha related blogs.