IGFBP-6 Antibody (RM0098-21D24)

Product Discontinued

IGFBP-6 Antibody (RM0098-21D24) Summary

• Immunogen: Mouse recombinant protein of IGFBP-6
• Specificity: This was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with mouse recombinant protein of IGFBP-6.
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Rat
• Gene: IGFBP6
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500-1:1000
• Application Notes: This antibody detects mouse IGFBP-6 in Western blotting. No cross activity to other mouse IGFBPs.

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from 0.2 um filtered PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Alternate Names for IGFBP-6 Antibody (RM0098-21D24)

• IBP6
• IBP-6
• IGF binding protein 6
• IGF-binding protein 6
• IGFBP6
• IGFBP-6
• insulin-like growth factor binding protein 6
• insulin-like growth factor-binding protein 6

Background

IGFBP6 (IGF binding protein 6) is a member of the IGFBP family that regulates the actions of IGFs. It acts extracellularly in an autocrine/paracrine manner. IGFBP6 binds preferentially to IGF-II. IGFBP6 has been shown to inhibit the growth of tumour cells and to promote apotosis. IGFBP6 has been shown to be imported into the nuclei of rhabdomyosarcoma and HEK-293 cells. This is mediated by a NLS sequence that bears limited homology to those found in IGFBP-3 and -5. Deletion of the NLS segment abolishes the pro-apoptotic effect of IGFBP6.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IGFBP6
• Entrez:
  • 3489(Human)