IFN-kappa Antibody (1009727) [Janelia Fluor® 525]

• Reactivity: Hu
• Applications: ELISA
• Clone: 1009727
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 525

IFN-kappa Antibody (1009727) [Janelia Fluor® 525] Summary

• Immunogen: E. coli-derived recombinant human IFN‑ kappa
  Leu28-Lys207
  Accession # Q90W0
• Specificity: Detects human IFN‑ kappa in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for IFN-kappa Antibody (1009727) [Janelia Fluor® 525]

• IFNK
• IFNkappa
• IFN-kappa

Background

IFN-kappa (Interferon kappa) is a secreted, nonglycosylated polypeptide that belongs to the IFN-kappa subclass of the type I interferon family of cytokines. It is expressed by macrophages in mice, and monocytes, dendritic cells and keratinocytes in human. IFN-kappa induces TNF-alpha, IL-10 and MCP-1 production by monocytes. Mouse IFN-kappa precursor is 199 amino acids (aa) in length. It contains a 21 aa signal sequence, plus a 178 aa mature region. There are two intrachain disulfide bonds plus a fifth unpaired cysteine. Mature mouse IFN-kappa (aa 22-199) shares 68% and 30% aa identity with rat and human IFN-kappa, respectively.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.