IFN-beta Antibody [Unconjugated]

• Reactivity: Hu
• Applications: B/N
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Unconjugated

IFN-beta Antibody [Unconjugated] Summary

• Immunogen: Recombinant human IFN‑ beta 1a (expressed in mammalian cells)
• Specificity: Detects human IFN‑ beta .
• Source: N/A
• Isotype: Serum
• Clonality: Polyclonal
• Host: Sheep
• Gene: IFNB1
• Purity Statement: N/A

Applications/Dilutions

• Dilutions:
  • Neutralization

Packaging, Storage & Formulations

• Storage: After receipt, the product may be stored at -20°C for short-term use (≤ 6 months). For long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).
• Buffer: Neat serum.
• Preservative: No Preservative

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for IFN-beta Antibody [Unconjugated]

• Fibroblast interferon
• IFB
• IFBIFNB
• IFF
• IFNB
• IFNB1
• IFNbeta
• IFN-beta
• interferon beta
• interferon, beta 1, fibroblast
• MGC96956

Background

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IFN-beta Antibody (31401-1)(1)

Publication using 31401-1

• Ka NL, Lim GY, Kim SS et al. Type I IFN stimulates IFI16-mediated aromatase expression in adipocytes that promotes E2-dependent growth of ER-positive breast cancer Cellular and molecular life sciences : CMLS 5/20/2022 [PMID: 35593921]
  
  Details:
  Fig. 3

Bioinformatics

• Gene Symbol: IFNB1