IFN-alpha/beta R1 Antibody (EPR6244)

Product Discontinued

IFN-alpha/beta R1 Antibody (EPR6244) Summary

• Immunogen: A synthetic peptide corresponding to residues in human IFN alpha R1 was used as an immunogen.
• Clonality: Monoclonal
• Host: Rabbit
• Gene: IFNAR1
• Purity: Tissue culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot 1:1000 - 10000

Reactivity Notes

Reacts with: Mouse, Rat, Human

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: 49% PBS, 0.05% BSA and 50% Glycerol
• Preservative: 0.01% Sodium Azide
• Purity: Tissue culture supernatant

Notes

Produced using Abcam's RabMab® technology. RabMab® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Alternate Names for IFN-alpha/beta R1 Antibody (EPR6244)

• alpha-type antiviral protein
• AVP
• beta-type antiviral protein
• CRF2-1
• Cytokine receptor class-II member 1
• Cytokine receptor family 2 member 1
• human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC
• IFN-alpha/beta R1
• IFN-alpha/beta receptor 1
• IFN-alpha-REC
• IFNAR
• IFNAR1
• IFN-aR1
• IFNBR
• IFNbR1
• IFN-bR1
• IFN-R-1
• interferon (alpha, beta and omega) receptor 1
• interferon alpha/beta receptor 1
• interferon-alpha/beta receptor alpha chain
• interferon-beta receptor 1
• Type I interferon receptor 1

Background

Interferon alpha receptor 1 (IFN alpha R1) is a class II cytokine receptor that belongs to the type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN alpha R1 is a 135-kDa signal transducing subunit of the IFN alpha/beta receptor complex (IFN-a R) (1). IFN alpha R1 is phosphorylated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN alpha R1 (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IFNAR1
• Uniprot:
  • P17181()