V2 Vasopressin R/AVPR2 Antibody - BSA Free

Immunohistochemistry-Paraffin: V2 Vasopressin R/AVPR2 Antibody [NLS272] - Colon, carcinoma

Immunohistochemistry-Paraffin: V2 Vasopressin R/AVPR2 Antibody [NLS272] - Analysis of anti-AVPR2 antibody with human kidney, renal tubules.

Immunohistochemistry-Paraffin: V2 Vasopressin R/AVPR2 Antibody [NLS272] - Human Lung, Adenocarcinoma tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: V2 Vasopressin R/AVPR2 Antibody [NLS272] - Human Breast, Carcinoma tissue after heat-induced antigen retrieval.

Immunohistochemistry-Paraffin: V2 Vasopressin R/AVPR2 Antibody [NLS272] - Ovary, carcinoma

Immunohistochemistry-Paraffin: V2 Vasopressin R/AVPR2 Antibody [NLS272] - Prostate, Carcinoma

• Reactivity: Hu, Mu, Rt, Ha, Pm, Rb, Bt, Ca, Pm, Pm-Or, Pm
• Applications: IHC
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1.0 mg/ml

V2 Vasopressin R/AVPR2 Antibody - BSA Free Summary

• Description: Product can be stored undiluted at 4C for up to 1 month.
• Immunogen: Synthetic 20 amino acid peptide from 3rd cytoplasmic domain of human V2 Vasopressin R/AVPR2.
• Epitope: 3rd cytoplasmic domain
• Localization: Cell Membrane
• Specificity: Human AVPR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
• Predicted Species: Orangutan (100%), Chimpanzee (100%), Bat (95%), Canine (90%), Primate (100%). Backed by our 100% Guarantee.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: AVPR2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin 26 ug/ml
• Application Notes: Use in IHC-Frozen reported in scientific literature (PMID: 23399889).
• Control:

  V2 Vasopressin R/AVPR2 Overexpression Lysate

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Baboon (95%), Bovine (80%).

Packaging, Storage & Formulations

• Storage: Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for V2 Vasopressin R/AVPR2 Antibody - BSA Free

• ADHR
• ADHRMGC138386
• Antidiuretic hormone receptor
• arginine vasopressin receptor 2
• AVPR V2
• AVPR2
• DI1
• DIR3
• DIRNDI
• NDI
• Renal-type arginine vasopressin receptor
• V2 Vasopressin R
• V2 VasopressinR
• V2R
• V2RMGC126533
• vasopressin V2 receptor

Background

The human AVPR2 locus encodes vasopressin receptor type 2, a member of the vasopressin/oxytocin family subfamily. V2 receptor has been shown to concentrate the urine and maintain water homeostasis by responding to the pituitary hormone arginine vasopressin (AVP). Loss of gene function results in the disease Nephrogenic Diabetes Insipidus (NDI). When extrarenal V2 receptors are stimulated by infusion of a V2 selective agonist (dDAVP), a variety of clotting factors are released into the bloodstream. The physiologic importance of this property is not known; its absence does not appear to be detrimental in NDI patients. The V2 receptor is expressed in the kidney tubule, predominantly in the distal convoluted tubule and collecting ducts. The V2 Receptor is also expressed outside the kidney although its tissue localization is uncertain. AVPR2 expression has also been described in brain, breast, fetal lung tissue and lung cancer associated with alternative splicing. ESTs have been isolated from normal lung and pancreatic cancer libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for V2 Vasopressin R/AVPR2 Antibody (NLS272)(1)

Publication using NLS272

• Kuzdas D, Stemberger S, Gaburro S et al. Oligodendroglial alpha-synucleinopathy and MSA-like cardiovascular autonomic failure: Experimental evidence. Exp Neurol 2013-02-08 [PMID: 23399889] (IHC-Fr, Mouse)

Bioinformatics

• Gene Symbol: AVPR2
• Entrez:
  • 554(Human)