IFN-alpha/beta R1 Products

Antibodies
IFN-alpha/beta R1 Antibody [U ...
IFN-alpha/beta R1 Antibody [Unconj...
AF245
Species: Hu
Applications: WB, Flow, CyTOF-ready
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
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IFN-alpha/beta R1 Antibody
IFN-alpha/beta R1 Antibody
AF3039
Species: Mu
Applications: WB, B/N
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
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Antibody Pairs
IFN-alpha/beta R1 Antibody Pa ...
IFN-alpha/beta R1 Antibody Pair [HRP]
NBP2-79589
Species: Mu
Applications: ELISA
Host: Rabbit
Conjugate Catalog # Availability Size Price
IFN-alpha/beta R1 Antibody Pa ...
IFN-alpha/beta R1 Antibody Pair [HRP]
NBP2-79412
Species: Hu
Applications: ELISA
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
Lysates
IFN-alpha/beta R1 Overexpress ...
IFN-alpha/beta R1 Overexpression L...
NBP2-04169
Species: Hu
Applications: WB
Proteins
Recombinant Cynomolgus Monkey ...
Recombinant Cynomolgus Monkey IFN-...
10674-AB
Species: Pm-Cm
Applications: Bioactivity
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Recombinant Human IFN-alpha/b ...
Recombinant Human IFN-alpha/beta R...
245-AB
Species: Hu
Applications: Bioactivity
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Recombinant Mouse IFN-alpha/b ...
Recombinant Mouse IFN-alpha/beta R...
3039-AB
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  

Description

Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).

Bioinformatics

Entrez Mouse
Rat
Human
Uniprot Human
Rat
Human
Human
Human
Alternate Names
  • alpha-type antiviral protein
  • AVP
  • beta-type antiviral protein
  • CRF2-1
  • Cytokine receptor class-II member 1
  • Cytokine receptor family 2 member 1
  • human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC
  • IFN-alpha/beta receptor 1
  • IFN-alpha-REC
  • IFNAR
  • IFNBR
  • IFN-R-1
  • interferon (alpha, beta and omega) receptor 1
  • interferon alpha/beta receptor 1
  • interferon-alpha/beta receptor alpha chain
  • interferon-beta receptor 1
  • Type I interferon receptor 1

Research Areas for IFN-alpha/beta R1

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Phospho-Specific