IFN-alpha/beta R1 Products

Description

Interferon alpha receptor 1 (IFN-alpha R1) is a class II cytokine receptor which belongs to type I human interferons (IFNs) family. IFNs plays a role in antiviral, antiproliferative, immunomodulatory, antitumor, and antiparasitic activities by inducing transcription of IFN-stimuated genes (ISGs) through activation of the Jak-STAT pathway. Specifically, IFN- R1 is a 135-kda signal transducing subunit of the IFN alpha/beta receptor complex (IFN-alpha R) (1). IFN-alpha R1 is phospholyated through PTK- and PKC-mediated phosphorylation, which initiates docking of STAT proteins to IFNs. This leads to activation of STAT proteins by PTK-mediated phosphorylation. The mechanism behind the amplification of IFN-alpha R complex mediated transmembrane signaling has been linked to tyrosine phosphorylation on IFN-alpha R1 (2).

Bioinformatics

Entrez	15975 Mouse 288264 Rat 3454 Human
Uniprot	AAA52730 Human D3ZDS9 Rat NP_000620 Human NP_000620.2 Human P17181 Human
Product By Gene ID	3454
Alternate Names	alpha-type antiviral protein AVP beta-type antiviral protein CRF2-1 Cytokine receptor class-II member 1 Cytokine receptor family 2 member 1 human interferon-alpha receptor (HuIFN-alpha-Rec)10IFRC IFN-alpha/beta receptor 1 IFN-alpha-REC IFNAR IFNBR IFN-R-1 interferon (alpha, beta and omega) receptor 1 interferon alpha/beta receptor 1 interferon-alpha/beta receptor alpha chain interferon-beta receptor 1 Type I interferon receptor 1

Research Areas for IFN-alpha/beta R1

Find related products by research area and learn more about each of the different research areas below.

Neuroscience
Phospho-Specific