IFIT3 Antibody

Western Blot: IFIT3 Antibody [H00003437-B01P] - Analysis of IFIT3 expression in human colon.

Western Blot: IFIT3 Antibody [H00003437-B01P] - Analysis of IFIT3 expression in A-431.

Western Blot: IFIT3 Antibody [H00003437-B01P] - Analysis of IFIT3 expression in transfected 293T cell line by IFIT3 polyclonal antibody. Lane 1: IFIT3 transfected lysate(53.9 KDa). Lane 2: Non-transfected lysate.

Product Discontinued

IFIT3 Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: IFIT3 (NP_001540, 1 a.a. - 490 a.a.) full-length human protein. MSEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYSDLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRDAPSGIGSIFLSASELEDGSEEMGQGAVSSSPRELLSNSEQLN
• Specificity: IFIT3 - interferon-induced protein with tetratricopeptide repeats 3,
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: IFIT3
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB and also on transfected lysate in WB. GST tag alone is used as a negative control. IHC-P usage reported in scientific literature (PMID: 25988820). Use in Immunohistochemistry reported in scientific literature (PMID: 23045702). Use in Immunohistochemistry reported in scientific literature (PMID: 23045702).

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for IFIT3 Antibody

• CIG-49
• GARG-49
• IFI60Retinoic acid-induced gene G protein
• IFIT-3
• IFIT-4
• IFIT4IFI-60K
• interferon-induced protein with tetratricopeptide repeats 3
• Interferon-induced protein with tetratricopeptide repeats 4Interferon-induced 60 kDa protein
• IRG2
• ISG60
• ISG-60
• RIG-GCIG49

Background

IFIT3, also known as IFIT4, IFI60, and RIGG, has been identified as a key element in the IFN-alpha anti-viral pathway. Additionally, IFIT3 binding negatively regulates the apoptotic effects of ISG54. IFIT3 is also a key target of STAT1, which is important in regulating IFN responses. One study has shown that expression of RIGG in a human monocytoma line led to growth arrest at the G1/S transition.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for IFIT3 Antibody (H00003437-B01P)(2)

Publications using H00003437-B01P

• Hall JC, Baer AN, Shah AA et al. Molecular subsetting of interferon pathways in Sjogren's syndrome. Arthritis & rheumatology. 2015-05-18 [PMID: 25988820] (WB, IHC-P, Human)
• Hall JC, Casciola-Rosen L, Berger AE et al. Precise probes of type II interferon activity define the origin of interferon signatures in target tissues in rheumatic diseases Proc Natl Acad Sci 2012-10-23 [PMID: 23045702] (IF/IHC, Human)

Bioinformatics

• Gene Symbol: IFIT3
• Entrez:
  • 3437(Human)
• Uniprot:
  • NP_001540(Human)