Human ULBP-1 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human ULBP-1 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: ULBP1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human ULBP-1 DuoSet ELISA, 15 Plate

• ALCAN-beta
• MULT-1
• N2DL1
• N2DL-1
• NKG2D ligand 1
• NKG2DL
• NKG2DL1
• RAET1I
• RAET1Ialcan-beta
• Retinoic acid early transcript 1I
• UL16 binding protein 1
• UL16-binding protein 1
• ULBP1
• ULBP-1

Background

ULBP-1, -2, and -3 were originally identified as ligands for the human cytomegalovirus glycoprotein UL16 and designated UL16-binding proteins (ULBP). These proteins are distantly related to major histocompatibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or interact with beta2-microglobulin. ULBP-1, -2, and -3 are known to bind to human NKG2D, an activating receptor expressed on NK cells, NKT cells, gamma delta T cells, and CD8+ alpha beta T cells.

MULT1 (mouse UL16-binding protein-like Transcript 1) is a 53 kDa, MHC Class I-like molecule that belongs to the mouse family of NKG2D ligands. It is a type I transmembrane glycoprotein that is synthesized as a 334 amino acid (aa) precursor. It contains a 25 aa signal sequence, a 186 aa extracellular region, a 19 aa transmembrane segment and a 104 aa cytoplasmic tail. The extracellular region contains an alpha-1 and alpha-2 like domain with two intrachain disulfide bonds.

Publications for ULBP-1 (DY1380)(5)

Publications using DY1380

• Vulpis, E;Loconte, L;Cassone, C;Antonangeli, F;Caracciolo, G;Masuelli, L;Fazio, F;Petrucci, MT;Fionda, C;Soriani, A;Cerboni, C;Cippitelli, M;Santoni, A;Zingoni, A; Cross-Dressing of Multiple Myeloma Cells Mediated by Extracellular Vesicles Conveying MIC and ULBP Ligands Promotes NK Cell Killing International journal of molecular sciences 2023-05-30 [PMID: 37298418] (Human)
• D Samarkanov, S Cox, D Hernandez, L Rodriguez, ML Pérez, A Madrigal, A Vilarrodon, S Querol, RP Casaroli-M Cord blood and amniotic membrane extract eye drop preparations display immune-suppressive and regenerative properties Scientific Reports, 2021-07-02;11(1):13754. 2021-07-02 [PMID: 34215804] (Human)
• Expression and prognostic significance of unique ULBPs in pancreatic cancer Onco Targets Ther, 2016-08-25;9(0):5271-9. 2016-08-25 [PMID: 27621649] (Human)
• Cox S, Laza-Briviesca R, Pearson H, Soria B, Gibson D, Gomez S, Madrigal J, Saudemont A Umbilical cord blood plasma contains soluble NKG2D ligands that mediate loss of natural killer cell function and cytotoxicity. Eur J Immunol, 2015-06-09;45(8):2324-34. 2015-06-09 [PMID: 25991034] (Human)
• Giannattasio A, Weil S, Kloess S, Ansari N, Stelzer E, Cerwenka A, Steinle A, Koehl U, Koch J Cytotoxicity and infiltration of human NK cells in in vivo-like tumor spheroids. BMC Cancer, 2015-05-03;15(0):351. 2015-05-03 [PMID: 25933805] (Human)

Bioinformatics

• Gene Symbol: ULBP1