Human TIMP-2 DuoSet ELISA, 15 Plate

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications ELISA
Conjugate
Biotin

Order Details

Human TIMP-2 DuoSet ELISA, 15 Plate Summary

Assay Type
Solid Phase Sandwich ELISA
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details
Gene
TIMP2

Applications/Dilutions

Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using DY971.

Packaging, Storage & Formulations

Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human TIMP-2 DuoSet ELISA, 15 Plate

  • CSC-21Ktissue inhibitor of metalloproteinase 2
  • metalloproteinase inhibitor 2
  • TIMP metallopeptidase inhibitor 2
  • TIMP2
  • TIMP-2
  • Tissue inhibitor of metalloproteinases 2

Background

TIMPs-1 through -4 regulate the activity of zinc metalloproteases known as MMPs, ADAMs and ADAMTSs. Structurally, TIMPs contain two domains. The N-terminal domain binds to the active site of mature metalloproteases via a 1:1 non-covalent interaction, blocking access of substrates to the catalytic site. In addition, The C-terminal domain of TIMP-1 and TIMP-2 binds to the hemopexin- like domain of pro-MMP-9 and pro-MMP-2, respectively. The latter binding is essential for the cell surface activation of MMP-2 by MMP-14.

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Publications for TIMP-2 (DY971)(10)

We have publications tested in 1 confirmed species: Human.


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Human
(10)
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Showing Publications 1 - 10 of 10.
Publications using DY971 Applications Species
TT Vuong, SB Rønning, TAE Ahmed, K Brathagen, V Høst, MT Hincke, HP Suso, ME Pedersen Processed eggshell membrane powder regulates cellular functions and increase MMP-activity important in early wound healing processes PLoS ONE, 2018;13(8):e0201975. 2018 [PMID: 30080894] (Human) Human
S Brilha, CWM Ong, B Weksler, N Romero, PO Couraud, JS Friedland Matrix metalloproteinase-9 activity and a downregulated Hedgehog pathway impair blood-brain barrier function in an in vitro model of CNS tuberculosis Sci Rep, 2017;7(1):16031. 2017 [PMID: 29167512] (Human) Human
CW Ong, PJ Pabisiak, S Brilha, P Singh, F Roncaroli, PT Elkington, JS Friedland Complex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosis J Neuroinflammation, 2017;14(1):31. 2017 [PMID: 28173836] (Human) Human
Rath T, Zwaschka L, Hage L, Kugler M, Menendez K, Naehrlich L, Schulz R, Roderfeld M, Roeb E Identification of neutrophil activation markers as novel surrogate markers of CF lung disease. PLoS ONE, 2014;9(12):e115847. 2014 [PMID: 25545245] (Human) Human
Tsai HC, Ye SY, Kunin CM, Lee SS, Wann SR, Tai MH, Shi MH, Liu YC, Chen YS Expression of matrix metalloproteinases and their tissue inhibitors in the serum and cerebrospinal fluid of patients with HIV-1 infection and syphilis or neurosyphilis. Cytokine, 2011;54(0):109-16. 2011 [PMID: 21354815] (Human) Human
Shyamsundar M, McKeown ST, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers. Am. J. Respir. Crit. Care Med., 2009;179(12):1107-14. 2009 [PMID: 19324974] (Human) Human
Sheen P, O'Kane CM, O'Kane CM, Chaudhary K, Tovar M, Santillan C, Sosa J, Caviedes L, Gilman RH, Stamp G, Friedland JS High MMP-9 activity characterises pleural tuberculosis correlating with granuloma formation. Eur. Respir. J., 2009;33(1):134-41. 2009 [PMID: 18715875] (Human) Human
Dietmann A, Helbok R, Lackner P, Issifou S, Lell B, Matsiegui PB, Reindl M, Schmutzhard E, Kremsner PG Matrix metalloproteinases and their tissue inhibitors (TIMPs) in Plasmodium falciparum malaria: serum levels of TIMP-1 are associated with disease severity. J. Infect. Dis., 2008;197(11):1614-20. 2008 [PMID: 18700258] (Human) Human
Tsai HC, Chung LY, Chen ER, Sy CL Association of matrix metalloproteinase-9 and tissue inhibitors of metalloproteinase-4 in cerebrospinal fluid with blood-brain barrier dysfunction in patients with eosinophilic meningitis caused by Angiostrongylus cantonensis. Am. J. Trop. Med. Hyg., 2008;78(1):20-7. 2008 [PMID: 18187780] (Human) Human
Bergin PJ, Anders E, Sicheng W, Erik J, Jennie A, Hans L, Pierre M, Qiang PH, Marianne QJ Increased production of matrix metalloproteinases in Helicobacter pylori-associated human gastritis. Helicobacter, 2004;9(0):201. 2004 [PMID: 15165255] (Human) Human

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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for TIMP-2 (DY971). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Other Available Formats

Biotin DY971

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Bioinformatics Tool for TIMP-2 (DY971)

Discover related pathways, diseases and genes to TIMP-2 (DY971). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Blogs on TIMP-2.

Suppressing breast cancer metastasis: The role of hypoxia-induced RhoB expression and activation
By Jamshed Arslan, Pharm. D., PhD. The Ras homologous (Rho) GTPase family of signaling molecules has over 20 members, which typically cycle between active (GTP-bound) and inactive (GDP-bound) states. These small GTPa...  Read full blog post.

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Bioinformatics

Gene Symbol TIMP2