Human sgp130 DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human sgp130 DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL6ST

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human sgp130 DuoSet ELISA, 15 Plate

• CD130 antigen
• CD130
• CDw130
• DKFZp564F053
• gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form
• gp130
• IL-6 receptor subunit beta
• IL-6R subunit beta
• IL-6RB
• IL-6R-beta
• IL6ST
• interleukin 6 signal transducer (gp130, oncostatin M receptor)
• interleukin receptor beta chain
• interleukin-6 receptor subunit beta
• Interleukin-6 signal transducer
• Membrane glycoprotein 130
• membrane glycoprotein gp130
• Oncostatin-M receptor subunit alpha

Background

Gp130, the common signal transducing receptor component shared by the functional receptor complexes of the IL-6 family of cytokines, belongs to the classI cytokine receptor family. Binding of IL-6 or IL-11 to either the membrane-anchored or soluble IL-6 R or IL-11 R, respectively, initiates the association of IL-6 R (IL-11 R) with gp130. The complex then undergoes homodimerization and signal transduction. For other IL-6 family cytokines, such as LIF and OSM, signal transduction is similarly triggered by the heterodimerization of gp130 with LIFR or OSM R.

Publications for gp130/CD130 (DY228)(10)

Publications using DY228

• Rodríguez-Hernández, MÁ;Baena-Bustos, M;Carneros, D;Zurita-Palomo, C;Muñoz-Pinillos, P;Millán, J;Padillo, FJ;Smerdou, C;von Kobbe, C;Rose-John, S;Bustos, M; Targeting IL-6 trans-signalling by sgp130Fc attenuates severity in SARS-CoV-2 -infected mice and reduces endotheliopathy EBioMedicine 2024-04-26 [PMID: 38677182] (Transgenic Mouse)
• LM Westermann, A Baranowsky, G Di Lorenzo, T Danyukova, J Soul, JM Schwartz, G Hendrickx, M Amling, S Rose-John, C Garbers, T Schinke, S Pohl Transgenic inhibition of interleukin-6 trans-signaling does not prevent skeletal pathologies in mucolipidosis type II mice Scientific Reports, 2021-02-11;11(1):3556. 2021-02-11 [PMID: 33574442] (Mouse)
• A Escrig, A Molinero, B Méndez, M Giralt, G Comes, P Sanchis, O Fernández-, L Giménez-Ll, C Becker-Pau, S Rose-John, J Hidalgo IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer's Disease Cells, 2020-07-02;9(7):. 2020-07-02 [PMID: 32630818] (Mouse)
• S Gupta, GY Junquera, L Nicassio, B Becknell, CB Ching Trans IL-6 signaling does not appear to play a role in renal scarring after urinary tract infection J Pediatr Urol, 2020-05-29;0(0):. 2020-05-29 [PMID: 32563691] (Human)
• NE McGregor, M Murat, J Elango, IJ Poulton, EC Walker, B Crimeen-Ir, PWM Ho, JH Gooi, TJ Martin, NA Sims IL-6 exhibits both cis and trans signaling in osteocytes and osteoblasts, but only�trans�signaling promotes bone formation and osteoclastogenesis J. Biol. Chem., 2019-03-28;0(0):. 2019-03-28 [PMID: 30923130] (Mouse)
• Broch K, Askevold E, Gjertsen E, Ueland T, Yndestad A, Godang K, Stueflotten W, Andreassen J, Svendsmark R, Smith H, Aakhus S, Aukrust P, Gullestad L The effect of rosuvastatin on inflammation, matrix turnover and left ventricular remodeling in dilated cardiomyopathy: a randomized, controlled trial. PLoS ONE, 2014-02-25;9(2):e89732. 2014-02-25 [PMID: 24586994] (Human)
• Zhao S, Gu Y, Dong Q, Fan R, Wang Y Altered interleukin-6 receptor, IL-6R and gp130, production and expression and decreased SOCS-3 expression in placentas from women with pre-eclampsia. Placenta, 2008-11-05;29(12):1024-8. 2008-11-05 [PMID: 18986700] (Human)
• Simon D, Denniston AK, Tomlins PJ, Wallace GR, Rauz S, Salmon M, Murray PI, Curnow SJ Soluble gp130, an antagonist of IL-6 transsignaling, is elevated in uveitis aqueous humor. Invest. Ophthalmol. Vis. Sci., 2008-05-09;49(9):3988-91. 2008-05-09 [PMID: 18469182] (Human)
• Hsu HY, Wittemann S, Schneider EM, Weiss M, Joos TO Suspension microarrays for the identification of the response patterns in hyperinflammatory diseases. Med Eng Phys, 2008-03-03;30(8):976-83. 2008-03-03 [PMID: 18313970] (Human)
• Rabe B, Chalaris A, May U, Waetzig GH, Seegert D, Williams AS, Jones SA, Rose-John S, Scheller J Transgenic blockade of interleukin 6 transsignaling abrogates inflammation. Blood, 2007-11-07;111(3):1021-8. 2007-11-07 [PMID: 17989316] (Transgenic Mouse)

FAQs for gp130/CD130 (DY228). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: IL6ST