Human Serum Amyloid A1 DuoSet ELISA, 5 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Serum Amyloid A1 DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: SAA1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Serum Amyloid A1 DuoSet ELISA, 5 Plate

• MGC111216
• PIG4
• SAA
• SAA1
• SAA2
• serum amyloid A protein
• Serum Amyloid A1
• TP53I4
• tumor protein p53 inducible protein 4

Background

The apolipoproteins are a structurally-unrelated group of proteins that have some association with the transport of lipids in blood. Apolipoproteins, plus phospholipids, cholesterol and triglycerides, form spherical particles with a lipid/hydrophobic center and a (apolipo)protein coat. The apolipoprotein coat promotes aqueous solubility and serves as a ligand for lipoprotein receptors. HDL may contain apolipoproteins A, C, D, E, J, L and M, while LDL contains apolipoproteins B and E.

ApoAI and ApoA2 are major protein components of serum high-density lipoprotein (HDL) and are produced by the liver and small intestine. They are involved in reverse cholesterol transport from tissues to the liver. Polymorphisms of ApoA2 are associated with disorders of cholesterol and fatty acid metabolism. Human ApoB (Apolipoprotein B-100) is a 550 kDa, secreted, palmitoylated glycoprotein that is part of LDL and VLDL particles. It is made by liver and is 4536 aa in length. It binds LDL to the ApoB/E receptor. ApoC activates lipoprotein lipase and may self-associate to form amyloid-type fibrils.

ApoE is a 34 kDa protein component of serum chylomicrons, VLDL, and HDL particles. It mediates the binding, uptake, and catabolism of these particles through interactions with the ApoE receptor and LDL receptors in the liver and brain. ApoE is important in fatty acid homeostasis and memory formation. Polymorphisms encode three variants (ApoE2, 3, 4) which are differentially related to the development of atherosclerosis and neurogenerative disorders, particularly Alzheimer's disease.

Serum amyloid A proteins (SAAs) are a family of homologous apolipoproteins of high density lipoprotein (HDL). They can be divided into two groups. The first group consists of the acute phase SAA1 and SAA2 that associate with HDL during inflammation and remodel the HDL particle by displacing apolipoprotein A1. The second group consists of constitutively expressed SAA4 and SAA5 that exist as minor apolipoproteins on HDL but make up more than 90% of the total SAA during homeostasis.

Publications for Serum Amyloid A1 (DY3019-05)(18)

Publications using DY3019-05

• Zhang, M;Li, H;Ma, S;Li, X;Xi, L;Li, Y;Zhang, Z;Zhang, S;Gao, Q;Huang, Q;Wan, J;Xie, W;Li, J;Yang, P;Zhang, Y;Zhai, Z; Serum proteome profiling reveals HGFA as a candidate biomarker for pulmonary arterial hypertension Respiratory research 2024-11-28 [PMID: 39609799] (Human)
• Custers, E;van der Burgh, YGR;Vreeken, D;Schuren, F;van den Broek, TJ;Verschuren, L;de Blaauw, I;Bouwens, M;Kleemann, R;Kiliaan, AJ;Hazebroek, EJ; Gastrointestinal complaints after Roux-en-Y gastric bypass surgery. Impact of microbiota and its metabolites Heliyon 2024-11-15 [PMID: 39559236] (Human)
• Beazer, JD;Sillars, A;Beck, S;Christoffersen, C;Ferraz, MJ;Mulder, MT;Graham, D;Karlsson, H;Ljunggren, S;Gill, J;Freeman, DJ; Favourable HDL composition in endurance athletes is not associated with changes in HDL in vitro antioxidant and endothelial anti-inflammatory function Bioscience reports 2024-10-30 [PMID: 39344511] (Human)
• Chen, DL;Chung, CM;Wang, GJ;Chang, KC; Lactate-to-albumin ratio and cholesterol levels predict neurological outcome in cardiac arrest survivors The American journal of emergency medicine 2024-06-25 [PMID: 38943710] (Human)
• K Wadowska, P B?asiak, A Rzechonek, I Bil-Lula, M ?liwi?ska- Hepcidin as a Diagnostic Biomarker in Anaemic Lung Cancer Patients Cancers, 2022-12-30;15(1):. 2022-12-30 [PMID: 36612220] (Human)
• H Lee, SY Kim, DW Kim, YS Park, JH Hwang, S Cho, JY Cho Serum protein profiling of lung, pancreatic, and colorectal cancers reveals alcohol consumption-mediated disruptions in early-stage cancer detection Heliyon, 2022-12-15;8(12):e12359. 2022-12-15 [PMID: 36590537] (Human)
• LN Hande, C Kjellmo, K Pettersen, S Ljunggren, H Karlsson, K Cederbrant, M Marcusson-, A Hovland, KT Lappegård Effect of N-3 Polyunsaturated Fatty Acids on Lipid Composition in Familial Hypercholesterolemia: A Randomized Crossover Trial Biomedicines, 2022-07-27;10(8):. 2022-07-27 [PMID: 36009356] (Human)
• M Roksandic, A Klisic, V Ceriman, J Kotur Stev, K Savic Vujo, D Mirkov, M Gajic, B Ilic, N Dimic, N Samardzic, D Jovanovic Oxidative stress and inflammation parameters-novel biomarkers for idiopathic pulmonary fibrosis European review for medical and pharmacological sciences, 2022-02-01;26(3):927-934. 2022-02-01 [PMID: 35179759] (Human)
• K Wadowska, P B?asiak, A Rzechonek, I Bil-Lula, M ?liwi?ska- New Insights on Old Biomarkers Involved in Tumor Microenvironment Changes and Their Diagnostic Relevance in Non-Small Cell Lung Carcinoma Biomolecules, 2021-08-13;11(8):. 2021-08-13 [PMID: 34439874] (Human)
• SA Ljunggren, LJ Ward, P Graff, A Persson, ML Lind, H Karlsson Metal additive manufacturing and possible clinical markers for the monitoring of exposure-related health effects PLoS ONE, 2021-03-18;16(3):e0248601. 2021-03-18 [PMID: 33735215] (Human)
• AM Thorne, H Huang, DP O'Brien, M Eijken, NV Krogstrup, R Norregaard, B Møller, RJ Ploeg, B Jespersen, BM Kessler Subclinical effects of remote ischaemic conditioning in human kidney transplants revealed by quantitative proteomics Clinical Proteomics, 2020-11-02;17(1):39. 2020-11-02 [PMID: 33292164] (Human)
• U Smole, N Gour, J Phelan, G Hofer, C Köhler, B Kratzer, PA Tauber, X Xiao, N Yao, J Dvorak, L Caraballo, L Puerta, S Rosskopf, J Chakir, E Malle, AP Lane, WF Pickl, S Lajoie, M Wills-Karp Serum amyloid A is a soluble pattern recognition receptor that drives type 2 immunity Nat. Immunol., 2020-06-22;21(7):756-765. 2020-06-22 [PMID: 32572240] (Human)
• C Jumeau, F Awad, E Assrawi, L Cobret, P Duquesnoy, I Giurgea, D Valeyre, G Grateau, S Amselem, JF Bernaudin, SA Karabina Expression of SAA1, SAA2 and SAA4 genes in human primary monocytes and monocyte-derived macrophages PLoS ONE, 2019-05-17;14(5):e0217005. 2019-05-17 [PMID: 31100086] (Human)
• S Ljunggren, T Bengtsson, H Karlsson, C Starkhamma, E Palm, F Nayeri, B Ghafouri, J Davies, G Svensäter, J Lönn Modified lipoproteins in periodontitis: a link to cardiovascular disease? Biosci. Rep., 2019-03-26;39(3):. 2019-03-26 [PMID: 30842338] (Human)
• Peijun J. W. He, Ioannis N. Katis, Robert W. Eason, Collin L. Sones Rapid Multiplexed Detection on Lateral-Flow Devices Using a Laser Direct-Write Technique Biosensors (Basel) 2018-10-20 [PMID: 30347807] (N/A)
• EJ Burgess, LR Hoyt, MJ Randall, MM Mank, JJ Bivona, PL Eisenhauer, JW Botten, BA Ballif, YW Lam, MJ Wargo, JE Boyson, JL Ather, ME Poynter Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A J. Immunol., 2018-08-29;0(0):. 2018-08-29 [PMID: 30158125] (Human)
• W Li, W Wang, R Zuo, C Liu, Q Shu, H Ying, K Sun Induction of pro-inflammatory genes by serum amyloid A1 in human amnion fibroblasts Sci Rep, 2017-04-06;7(1):693. 2017-04-06 [PMID: 28386088] (Human)
• Mats Lindahl Alterations in high-density lipoprotein proteome and function associated with persistent organic pollutants Environ Int, 2016-11-16;98(0):204-211. 2016-11-16 [PMID: 27865523] (Human)

FAQs for Serum Amyloid A1 (DY3019-05). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: SAA1