Human Serpin G1/C1 Inhibitor (Plasma) Protein, CF Summary
Details of Functionality
Measured by its ability to inhibit Recombinant Human Complement Component C1s (Catalog # 2060-SE) cleavage of a colorimetric peptide substrate, N-carbobenzyloxy-Lys-ThioBenzyl ester (Z-K-SBzl). The IC50 is <2.6 nM, as measured under the described conditions.
Human plasma-derived Serpin G1/C1 Inhibitor protein The human plasma used for the isolation of this product were certified by the supplier to be HIV-1 and HBsAg negative at the time of shipment. Human blood products should always be treated in accordance with universal handling precautions.
>95%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
<1.0 EU per 1 μg of the protein by the LAL method.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Human Serpin G1/C1 Inhibitor (Plasma) Protein, CF
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
As a member of the serpin superfamily of serine protease inhibitors, Serpin G1/C1 inhibitor is the physiological inhibitor of activated C1r and C1s, two serine proteases involved in the classical complement pathway. In addition, it inhibits plasma kallikrein and coagulation factor XIIa, two serine proteases involved in the processing of kininogen to release bradykinin. Therefore, it plays an important role in regulating activation of both the complement and contact systems (1). Serpin G1 deficiency results in hereditary angioedema, which is characterized by recurrent episodes of localized angioedema of the skin, gastrointestinal mucosa or upper respiratory mucosa (2). The deduced amino acid sequence of human Serpin G1 precursor consists of 500 residues with a signal peptide. The mature protein of 478 amino acid residues is heavily glycosylated (1).
Davis, A.E. III et al. (1993) Methods Enzymol. 223:97.
Davis, A.E. III (2004) Drug News Perspect. 17:439.
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