Human IL-36 beta/IL-1F8 DuoSet ELISA, 5 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-36 beta/IL-1F8 DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL36B

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-36 beta/IL-1F8 DuoSet ELISA, 5 Plate

• family of interleukin 1-eta
• FIL1 eta
• FIL1
• FIL1-(ETA)
• FIL1H
• FILI-(ETA)
• IL-1 eta
• IL1-ETA
• IL1F8 (Canonical product IL-1F8a)
• IL-1F8 (FIL1-eta)
• IL1F8
• IL-1F8
• IL1H2
• IL-1H2
• IL36 beta
• IL-36 beta
• IL36B
• interleukin 1 family, member 8 (eta)
• interleukin 1, eta
• Interleukin 36, Beta
• Interleukin-1 eta
• interleukin-1 family member 8
• Interleukin-1 homolog 2
• Interleukin-1 Superfamily e
• Interleukin-36 Beta

Background

Interleukin 36 beta (IL-36 beta), also known as IL-1F8, FIL-1h and IL-1H2, is a member of the IL-1 family of proteins. IL-36 beta is reported to be actively secreted. Cells expressing IL-36 beta include resting and activated monocytes, and B cells. The receptor for IL-36 beta is thought to be a combination of IL-1 Rrp2 and IL-1 RAcP. Recombinant IL-36 beta activates pathways involving NF-kB and MAPK in an IL-1 Rrp2-dependent manner.

Publications for IL-36 beta/IL-1F8 (DY1099-05)(6)

Publications using DY1099-05

• Komaki, R;Miyagaki, T;Tanaka, M;Nakajima, K;Okano, T;Takeuchi, S;Kadono, T; Increased Interleukin-36 beta Expression Promotes Angiogenesis in Japanese Atopic Dermatitis International journal of molecular sciences 2023-07-05 [PMID: 37446281] ( Human)
• X Gao, PKS Chan, GCY Lui, DSC Hui, IM Chu, X Sun, MS Tsang, BCL Chan, CW Lam, CK Wong Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections Cell Death & Disease, 2021-01-07;12(1):53. 2021-01-07 [PMID: 33414457] (Human)
• QX Zhang, Y Li, SM Jiang, LJ Zhang, M Yi, J Wang, Y Qi, L Yang, CS Yang Increased serum IL-36gamma levels are associated with disease severity in myasthenia gravis patients BMC Neurol, 2020-08-19;20(1):307. 2020-08-19 [PMID: 32814555] (Human)
• L Mercurio, CM Failla, L Capriotti, C Scarponi, F Facchiano, M Morelli, S Rossi, G Pagnanelli, C Albanesi, A Cavani, S Madonna Interleukin (IL)-17/IL-36 axis participates to the crosstalk between endothelial cells and keratinocytes during inflammatory skin responses PLoS ONE, 2020-04-30;15(4):e0222969. 2020-04-30 [PMID: 32352958] (Human)
• E Giannoudak, YE Hernandez-, K Mulfaul, SL Doyle, E Hams, PG Fallon, A Mat, D O'Shea, M Kopf, AE Hogan, PT Walsh Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction Nat Commun, 2019-09-05;10(1):4003. 2019-09-05 [PMID: 31488830] (Human)
• X Qin, M Liu, S Zhang, C Wang, T Zhang The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis Cytokine, 2019-03-01;117(0):84-90. 2019-03-01 [PMID: 30831444] (Human)

Bioinformatics

• Gene Symbol: IL36B