Human IL-36 alpha/IL-1F6 DuoSet ELISA, 5 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human IL-36 alpha/IL-1F6 DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: IL36A

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human IL-36 alpha/IL-1F6 DuoSet ELISA, 5 Plate

• FIL1 epsilon
• FIL1
• FIL1(EPSILON)
• FIL1E
• IL-1 epsilon
• IL1(EPSILON)
• IL1E
• IL-1E
• IL-1F6 (FIL-1-epsilon)
• IL1F6
• IL-1F6
• IL36 alpha
• IL-36 alpha
• IL36A
• interleukin 1 family, member 6 (epsilon)
• interleukin 1, epsilon
• Interleukin 36, Alpha
• Interleukin-1 epsilon
• interleukin-1 family member 6
• Interleukin-36 Alpha

Background

Interleukin 36 alpha (IL-36 alpha), also known as IL-1F6 and FIL1 epsilon, is a member of the IL-1 family of proteins. Cells reported to express IL-36 alpha include monocytes, B cells, and T cells. Notably, IL-36 alpha is the only novel IL-1 family member expressed on T-cells. The receptor for IL-36 alpha is reported to be a combination of IL-1 R6/IL-1 R rp2 and IL-1 R3/IL-1 R AcP. Recombinant IL-36 alpha has been shown to activate pathways involving NF-kappa B and MAPK in an IL-1 R6/IL-1 R rp2-dependent manner.

Publications for IL-36 alpha/IL-1F6 (DY1078-05)(8)

Publications using DY1078-05

• S O'Reilly Interleukin-36alpha is elevated in diffuse systemic sclerosis and may potentiate fibrosis Cytokine, 2022-06-03;156(0):155921. 2022-06-03 [PMID: 35667282] (Human)
• JM Li, R Lu, Y Zhang, J Lin, X Hua, SC Pflugfelde, DQ Li IL-36alpha/IL-36RA/IL-38 signaling mediates inflammation and barrier disruption in human corneal epithelial cells under hyperosmotic stress The ocular surface, 2021-08-21;22(0):163-171. 2021-08-21 [PMID: 34428579] (Human)
• X Xie, H Hu, J He, Y Liu, F Guo, F Luo, M Jiang, L Wang Interleukin-36&alpha suppresses growth of non-small cell lung cancer in vitro by reducing angiogenesis FEBS Open Bio, 2021-05-02;11(5):1353-1363. 2021-05-02 [PMID: 33713575] (Human)
• X Gao, PKS Chan, GCY Lui, DSC Hui, IM Chu, X Sun, MS Tsang, BCL Chan, CW Lam, CK Wong Interleukin-38 ameliorates poly(I:C) induced lung inflammation: therapeutic implications in respiratory viral infections Cell Death & Disease, 2021-01-07;12(1):53. 2021-01-07 [PMID: 33414457] (Human)
• QX Zhang, Y Li, SM Jiang, LJ Zhang, M Yi, J Wang, Y Qi, L Yang, CS Yang Increased serum IL-36gamma levels are associated with disease severity in myasthenia gravis patients BMC Neurol, 2020-08-19;20(1):307. 2020-08-19 [PMID: 32814555] (Human)
• L Mercurio, CM Failla, L Capriotti, C Scarponi, F Facchiano, M Morelli, S Rossi, G Pagnanelli, C Albanesi, A Cavani, S Madonna Interleukin (IL)-17/IL-36 axis participates to the crosstalk between endothelial cells and keratinocytes during inflammatory skin responses PLoS ONE, 2020-04-30;15(4):e0222969. 2020-04-30 [PMID: 32352958] (Human)
• E Giannoudak, YE Hernandez-, K Mulfaul, SL Doyle, E Hams, PG Fallon, A Mat, D O'Shea, M Kopf, AE Hogan, PT Walsh Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction Nat Commun, 2019-09-05;10(1):4003. 2019-09-05 [PMID: 31488830] (Human)
• X Qin, M Liu, S Zhang, C Wang, T Zhang The role of IL-36? and its regulation in eosinophilic inflammation in allergic rhinitis Cytokine, 2019-03-01;117(0):84-90. 2019-03-01 [PMID: 30831444] (Human)

FAQs for IL-36 alpha/IL-1F6 (DY1078-05). (Showing 1 - 1 of 1 FAQs).

1. wondering what the difference is between your quantikine and duo set elisas?
   • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

Bioinformatics

• Gene Symbol: IL36A