Human CXCL1/GRO alpha DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human CXCL1/GRO alpha DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: CXCL1

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human CXCL1/GRO alpha DuoSet ELISA, 15 Plate

• CINC1
• CINC-1
• CXCL1
• FSP
• GRO alpha
• GRO1
• GROa
• KC
• MGSA
• MGSA-a
• MGSA-alpha
• NAP-3
• SCYB1

Background

CXCL1/GRO alpha, also known as KC in mouse and CINC-1 in rat, is a member of the CXC family of chemokines. Human CXCL1/GRO alpha is 107 amino acids (aa) in length with a predicted molecular weight of 11 kDa. The mouse and rat orthologs share 57% and 59% amino acid sequence identity with the human protein, respectively. Genome-wide analysis suggests that the protein encoded by the mouse Cxcl3 gene is homologous to human CXCL1/GRO alpha protein. Human CXCL1/GRO alpha can be cleaved into three isoforms CXCL1/GRO alpha (aa 4-73), CXCL1/GRO alpha (aa 5-73), and CXCL1/GRO alpha (aa 6-73) which show higher activity than the full length protein. CXCL1/GRO alpha is secreted by mast cells and macrophages whereupon it acts as a chemoattractant for neutrophils.

Publications for CXCL1/GRO alpha/KC/CINC-1 (DY275)(69)

Publications using DY275

• Thazhathveettil, J;Gomez, SA;Olaoseeji, D;Wu, R;Sirsjö, A;Paramel, GV; Atherosclerotic Plaque Crystals Induce Endothelial Dysfunction International journal of molecular sciences 2025-10-07 [PMID: 41097024] (Human)
• Wu, Y;Shen, J;Gao, S;Li, M;Weng, Q;Zheng, K;Zhu, C;Qin, Z;Li, J;Lou, J;Ying, S;Wu, Y;Chen, Z;Li, W; Fatty acid synthase-mediated lipid droplet formation enhances macrophage killing of Staphylococcus aureus Cell death & disease 2025-10-07 [PMID: 41057302] (Mouse)
• Molczyk, C;Sturgeon, R;Saxena, S;Johnsson, E;Bhatia, R;Bhyrabhatla, N;Kumar, S;Batra, SK;Singh, RK; Unlocking the Power of CXCR2 Inhibition to Overcome Gemcitabine Resistance in Pancreatic Cancer bioRxiv : the preprint server for biology 2025-06-28 [PMID: 40667309] (Human)
• Brunner, M;Guggisberg, D;Sprecher, M;Pastva, O;Bürki, K;Houtman, M;Kreuzer, M;Krättli, SA;Jahnke, L;Roceri, M;Bruggmann, R;Elhai, M;Maurer, B;Marti, TM;Ospelt, C;Klein, K; Pro-Inflammatory Properties of Salivary Gland-Derived Fibroblasts-Implications in Sjögren's Disease Cells 2025-04-08 [PMID: 40277884] (Human)
• Somova, M;Simm, S;Ehrhardt, J;Schoon, J;Burchardt, M;Pinto, PC; SARS-CoV-2 Spike Protein Amplifies the Immunogenicity of Healthy Renal Epithelium in the Presence of Renal Cell Carcinoma Cells 2024-12-10 [PMID: 39768130] (ELISA, Human)
• Kuret, T;Sterle, I;Romih, R;Verani?, P; Matched serum- and urine-derived biomarkers of interstitial cystitis/bladder pain syndrome PloS one 2024-12-31 [PMID: 39739829] (Human)
• Shepelkova, GS;Evstifeev, VV;Berezovskiy, YS;Ergeshova, AE;Tarasov, RV;Bagirov, MA;Yeremeev, VV; Characteristics of Pulmonary Inflammation in Patients with Different Forms of Active Tuberculosis International journal of molecular sciences 2024-11-02 [PMID: 39519346] (Human)
• Reedy, JL;Jensen, KN;Crossen, AJ;Basham, KJ;Ward, RA;Reardon, CM;Brown Harding, H;Hepworth, OW;Simaku, P;Kwaku, GN;Tone, K;Willment, JA;Reid, DM;Stappers, MHT;Brown, GD;Rajagopal, J;Vyas, JM; Fungal melanin suppresses airway epithelial chemokine secretion through blockade of calcium fluxing Nature communications 2024-07-10 [PMID: 38987270] (Human)
• Weinelt, N;Wächtershäuser, KN;Celik, G;Jeiler, B;Gollin, I;Zein, L;Smith, S;Andrieux, G;Das, T;Roedig, J;Feist, L;Rotter, B;Boerries, M;Pampaloni, F;van Wijk, SJL; LUBAC-mediated M1 Ub regulates necroptosis by segregating the cellular distribution of active MLKL Cell death & disease 2024-01-20 [PMID: 38245534] (Human)
• Grabarczyk, M;Ksiazek-Winiarek, D;Glabinski, A;Szpakowski, P; Dietary Polyphenols Decrease Chemokine Release by Human Primary Astrocytes Responding to Pro-Inflammatory Cytokines Pharmaceutics 2023-09-07 [PMID: 37765263] (Human)
• Liu, Y;Smith, MR;Wang, Y;D'Agostino, R;Ruiz, J;Lycan, T;Kucera, GL;Miller, LD;Li, W;Chan, MD;Farris, M;Su, J;Song, Q;Zhao, D;Chandrasekaran, A;Xing, F; c-Met Mediated Cytokine Network Promotes Brain Metastasis of Breast Cancer by Remodeling Neutrophil Activities Cancers 2023-05-05 [PMID: 37174093]
• T Kuret, ME Kreft, R Romih, P Verani? Cannabidiol as a Promising Therapeutic Option in IC/BPS: In Vitro Evaluation of Its Protective Effects against Inflammation and Oxidative Stress International Journal of Molecular Sciences, 2023-03-06;24(5):. 2023-03-06 [PMID: 36902479] (Human)
• L Chen, V Shi, S Wang, R Freeman, F Ruiz, K Jayachandr, J Zhang, P Cosper, L Sun, CJ Luke, C Spina, PW Grigsby, JK Schwarz, S Markovina SCCA1/SERPINB3 promotes suppressive immune environment via STAT-dependent chemokine production, blunting the therapy-induced T cell responses bioRxiv : the preprint server for biology, 2023-02-03;0(0):. 2023-02-03 [PMID: 36778224] (Human)
• J Yang, L Jin, HS Kim, F Tian, Z Yi, K Bedi, M Ljungman, M Pasca di M, H Crawford, J Shi KDM6A Loss Recruits Tumor-Associated Neutrophils and Promotes Neutrophil Extracellular Trap Formation in Pancreatic Cancer Cancer Research, 2022-11-15;0(0):OF1-OF14. 2022-11-15 [PMID: 36306422] (Human)
• P Szpakowski, D Ksiazek-Wi, M Turniak-Ku, I Pacan, A Glabinski Human Primary Astrocytes Differently Respond to Pro- and Anti-Inflammatory Stimuli Biomedicines, 2022-07-22;10(8):. 2022-07-22 [PMID: 35892669] (Human)
• S Rutecki, P Szulc, M Paku?a, P Uruski, A Radziemski, E Naumowicz, R Moszy?ski, A Tykarski, J Miku?a-Pie, K Ksi??ek Pro-cancerogenic effects of spontaneous and drug-induced senescence of ovarian cancer cells in vitro and in vivo: a comparative analysis Journal of ovarian research, 2022-07-26;15(1):87. 2022-07-26 [PMID: 35883110] (Human)
• E Filidou, L Kandilogia, G Tarapatzi, M Spathakis, P Steiropoul, D Mikroulis, K Arvanitidi, V Paspaliari, G Kolios Anti-Inflammatory and Anti-Fibrotic Effect of Immortalized Mesenchymal-Stem-Cell-Derived Conditioned Medium on Human Lung Myofibroblasts and Epithelial Cells International Journal of Molecular Sciences, 2022-04-20;23(9):. 2022-04-20 [PMID: 35562961] (Human)
• L Lu, R Przybylla, Y Shang, M Dai, M Krohn, OH Krämer, CS Mullins, M Linnebache Microsatellite Status and IkappaBalpha Expression Levels Predict Sensitivity to Pharmaceutical Curcumin in Colorectal Cancer Cells Cancers, 2022-02-17;14(4):. 2022-02-17 [PMID: 35205780] (Human)
• S Saxena, C Molczyk, A Purohit, E Ehrhorn, P Goel, DR Prajapati, P Atri, S Kaur, PM Grandgenet, MA Hollingswo, SK Batra, RK Singh Differential expression profile of CXC-receptor-2 ligands as potential biomarkers in pancreatic ductal adenocarcinoma American journal of cancer research, 2022-01-15;12(1):68-90. 2022-01-15 [PMID: 35141005] (Human)
• J Queen, JC Domingue, JR White, C Stevens, B Udayasurya, TTD Nguyen, S Wu, H Ding, H Fan, M McMann, A Corona, TC Larman, SS Verbridge, F Housseau, DJ Slade, JL Drewes, CL Sears Comparative Analysis of Colon Cancer-Derived Fusobacterium nucleatum Subspecies: Inflammation and Colon Tumorigenesis in Murine Models MBio, 2022-02-08;0(0):e0299121. 2022-02-08 [PMID: 35130731] (Human)
• S Cambier, M Metzemaeke, AC Carvalho, A Nooyens, C Jacobs, L Vanderbeke, B Malengier-, M Gouwy, E Heylen, P Meersseman, G Hermans, E Wauters, A Wilmer, C Consortium, D Schols, P Matthys, G Opdenakker, RE Marques, J Wauters, J Vandooren, P Proost Atypical response to bacterial co-infection and persistent neutrophilic broncho-alveolar inflammation distinguish critical COVID-19 from influenza JCI Insight, 2022-01-11;0(0):. 2022-01-11 [PMID: 34793331] (Human)
• D Cela, SL Knackstedt, S Groves, CM Rice, JTW Kwon, B Mordmüller, B Amulic PAD4 controls chemoattractant production and neutrophil trafficking in malaria Journal of leukocyte biology, 2021-11-10;0(0):. 2021-11-10 [PMID: 34755385] (Human)
• N Niu, J Yao, RC Bast, AK Sood, J Liu IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming Oncogenesis, 2021-09-29;10(9):65. 2021-09-29 [PMID: 34588424] (Human)
• Z Yang, G Xu, B Wang, Y Liu, L Zhang, T Jing, M Tang, X Xu, K Jiao, L Xiang, Y Fu, D Tang, X Zhang, W Jin, G Zhuang, X Zhao, Y Liu USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade Nature Communications, 2021-08-11;12(1):4852. 2021-08-11 [PMID: 34381028] (Human)
• Z Cui, H Dabas, BC Leonard, JV Shiah, JR Grandis, DE Johnson Caspase-8 mutations associated with head and neck cancer differentially retain functional properties related to TRAIL-induced apoptosis and cytokine induction Cell Death & Disease, 2021-08-06;12(8):775. 2021-08-06 [PMID: 34362880] (Human)
• L Kandilogia, E Filidou, I Drygiannak, G Tarapatzi, S Didaskalou, M Koffa, K Arvanitidi, G Bamias, V Valatas, V Paspaliari, G Kolios Development of a Human Intestinal Organoid Model for In Vitro Studies on Gut Inflammation and Fibrosis Stem Cells International, 2021-07-27;2021(0):9929461. 2021-07-27 [PMID: 34354753] (Human)
• G Liu, H Li, W Zhang, J Yu, X Zhang, R Wu, M Niu, X Liu, R Yu Csnk1a1 inhibition modulates the inflammatory secretome and enhances response to radiotherapy in glioma Journal of Cellular and Molecular Medicine, 2021-07-03;0(0):. 2021-07-03 [PMID: 34216174] (Human)
• S Xia, J Wu, W Zhou, M Zhang, K Zhao, J Liu, D Tian, J Liao SLC7A2 deficiency promotes hepatocellular carcinoma progression by enhancing recruitment of myeloid-derived suppressors cells Cell Death & Disease, 2021-06-02;12(6):570. 2021-06-02 [PMID: 34108444] (Human)
• HK Skovdahl, S Gopalakris, TD Svendsen, AVB Granlund, I Bakke, ZG Ginbot, S Thorsvik, A Flatberg, B Sporsheim, J Ostrop, TE Mollnes, AK Sandvik, T Bruland Patient Derived Colonoids as Drug Testing Platforms-Critical Importance of Oxygen Concentration Frontiers in Pharmacology, 2021-05-13;12(0):679741. 2021-05-13 [PMID: 34054553] (Human)
• L Wang, D Aschenbren, Z Zeng, X Cao, D Mayr, M Mehta, M Capitani, N Warner, J Pan, L Wang, Q Li, T Zuo, S Cohen-Keda, J Lu, RC Ardy, DJ Mulder, D Dissanayak, K Peng, Z Huang, X Li, Y Wang, X Wang, S Li, S Bullers, AN Gammage, K Warnatz, AI Schiefer, G Krivan, V Goda, WHA Kahr, M Lemaire, Genomics E, CY Lu, I Siddiqui, MG Surette, D Kotlarz, KR Engelhardt, HR Griffin, R Rottapel, H Decaluwe, RM Laxer, M Proietti, S Hambleton, S Elcombe, CH Guo, B Grimbacher, I Dotan, SC Ng, SA Freeman, SB Snapper, C Klein, K Boztug, Y Huang, D Li, HH Uhlig, AM Muise Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice Nature Genetics, 2021-03-29;53(4):500-510. 2021-03-29 [PMID: 33782605] (Human)
• GK Vasileiadi, AC Lundell, Y Zhang, K Andersson, I Gjertsson, A Rudin, C Maglio Adipocytokines in Untreated Newly Diagnosed Rheumatoid Arthritis: Association with Circulating Chemokines and Markers of Inflammation Biomolecules, 2021-02-21;11(2):. 2021-02-21 [PMID: 33669910] (Human)
• H Salvator, A Buenestado, M Brollo, E Naline, T Victoni, E Longchamp, H Tenor, S Grassin-De, P Devillier Clinical Relevance of the Anti-inflammatory Effects of Roflumilast on Human Bronchus: Potentiation by a Long-Acting Beta-2-Agonist Frontiers in Pharmacology, 2020-12-08;11(0):598702. 2020-12-08 [PMID: 33363471] (Human)
• CA Ciocan-Car, A Jurj, O Zanoaga, R Cojocneanu, LA Pop, A Moldovan, C Moldovan, AA Zimta, L Raduly, C Pop-Bica, M Buse, L Budisan, P Virag, A Irimie, SMG Diaz, I Berindan-N, C Braicu New insights in gene expression alteration as effect of doxorubicin drug resistance in triple negative breast cancer cells J Exp Clin Cancer Res, 2020-11-13;39(1):241. 2020-11-13 [PMID: 33187552] (Human)
• J Sellau, M Groneberg, H Fehling, T Thye, S Hoenow, C Marggraff, M Weskamm, C Hansen, S Stanelle-B, S Kuehl, J Noll, V Wolf, NG Metwally, SH Hagen, C Dorn, J Wernecke, H Ittrich, E Tannich, T Jacobs, I Bruchhaus, M Altfeld, H Lotter Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1 Nat Commun, 2020-07-10;11(1):3459. 2020-07-10 [PMID: 32651360] (Human)
• HI Muendlein, J Sarhan, BC Liu, WM Connolly, SA Schworer, I Smirnova, AY Tang, V Ilyukha, J Pietruska, S Tahmasebi, N Sonenberg, A Degterev, A Poltorak Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation Cell Rep, 2020-01-21;30(3):699-713.e4. 2020-01-21 [PMID: 31968247] (Human)
• R Riise, L Odqvist, J Mattsson, S Monkley, SM Abdillahi, C Tyrchan, D Muthas, LF Yrlid Bleomycin hydrolase regulates the release of chemokines important for inflammation and wound healing by keratinocytes Sci Rep, 2019-12-31;9(1):20407. 2019-12-31 [PMID: 31892708] (Human)
• A Kivihall, A Aab, J Soja, K S?adek, M Sanak, A Altraja, B Jakiela, G Bochenek, A Rebane Reduced expression of miR-146a in human bronchial epithelial cells alters neutrophil migration Clin Transl Allergy, 2019-11-27;9(0):62. 2019-11-27 [PMID: 31798831] (Human)
• J Saliba, B Coutaud, V Solovieva, F Lu, V Blank Regulation of CXCL1 chemokine and CSF3 cytokine levels in myometrial cells by the MAFF transcription factor J. Cell. Mol. Med., 2019-01-22;0(0):. 2019-01-22 [PMID: 30669188] (Human)
• L Björkman, K Christenso, L Davidsson, J Mårtensson, F Amirbeagi, A Welin, H Forsman, A Karlsson, C Dahlgren, J Bylund Neutrophil recruitment to inflamed joints can occur without cellular priming J. Leukoc. Biol., 2018-12-20;0(0):. 2018-12-20 [PMID: 30570778] (Human)
• KC Jamieson, SL Traves, C Kooi, S Wiehler, CJ Dumonceaux, BA Maciejewsk, JW Arnason, AN Michi, R Leigh, D Proud Rhinovirus and Bacteria Synergistically Induce IL-17C Release from Human Airway Epithelial Cells To Promote Neutrophil Recruitment J. Immunol., 2018-11-30;0(0):. 2018-11-30 [PMID: 30504421] (Human)
• S Liong, G Barker, M Lappas Placental Ras Regulates Inflammation Associated with Maternal Obesity Mediators Inflamm., 2018-10-08;2018(0):3645386. 2018-10-08 [PMID: 30402038] (Human)
• J Chorachoo, S Lambert, T Furnholm, L Roberts, L Reingold, S Auepemkiat, SP Voravuthik, A Johnston The small molecule rhodomyrtone suppresses TNF-? and IL-17A-induced keratinocyte inflammatory responses: A potential new therapeutic for psoriasis PLoS ONE, 2018-10-15;13(10):e0205340. 2018-10-15 [PMID: 30321197] (Human)
• SE Logue, EP McGrath, P Cleary, S Greene, K Mnich, A Almanza, E Chevet, RM Dwyer, A Oommen, P Legembre, F Godey, EC Madden, B Leuzzi, J Obacz, Q Zeng, JB Patterson, R Jäger, AM Gorman, A Samali Inhibition of IRE1 RNase activity modulates the tumor cell secretome and enhances response to chemotherapy Nat Commun, 2018-08-15;9(1):3267. 2018-08-15 [PMID: 30111846] (Human)
• M Lyman, V Lieuw, R Richardson, A Timmer, C Stewart, S Granger, R Woods, M Silacci, D Grabulovsk, R Newman A bispecific antibody that targets IL-6 receptor and IL-17A for the potential therapy of patients with autoimmune and inflammatory diseases J. Biol. Chem., 2018-04-20;0(0):. 2018-04-20 [PMID: 29678878] (Human)
• Paul J Brighton, Yojiro Maruyama, Katherine Fishwick, Pavle Vrljicak, Shreeya Tewary, Risa Fujihara et al. Clearance of senescent decidual cells by uterine natural killer cells in cycling human endometrium eLife 2017-12-11 [PMID: 29227245] (Human)
• J Miku?a-Pie, P Uruski, S Szubert, K Maksin, R Moszy?ski, D Szpurek, A Wo?niak, S Sajdak, A Tykarski, K Ksi??ek The Proangiogenic Capabilities of Malignant Ascites Generated by Aggressive Ovarian Tumors Biomed Res Int, 2017-09-20;2017(0):2592496. 2017-09-20 [PMID: 29085834] (Human)
• YF Zhao, L Zhu, LJ Liu, SF Shi, JC Lv, H Zhang Pathogenic role of glycan-specific IgG antibodies in IgA nephropathy BMC Nephrol, 2017-09-29;18(1):301. 2017-09-29 [PMID: 28969604] (Human)
• DM Baston-Bue, O Altergot-A, SJ Pour, JS Krüssel, UR Markert, TN Fehm, AP Bielfeld Syndecan-1 Acts as an Important Regulator of CXCL1 Expression and Cellular Interaction of Human Endometrial Stromal and Trophoblast Cells Mediators Inflamm., 2017-02-15;2017(0):8379256. 2017-02-15 [PMID: 28293067] (Human)
• T Hartwig, A Montinaro, S von Karste, A Sevko, S Surinova, A Chakravart, L Taraborrel, P Draber, E Lafont, F Arce Varga, MA El-Bahrawy, SA Quezada, H Walczak The TRAIL-Induced Cancer Secretome Promotes a Tumor-Supportive Immune Microenvironment via CCR2 Mol. Cell, 2017-02-16;65(4):730-742.e5. 2017-02-16 [PMID: 28212753] (Human)
• CM Henry, SJ Martin Caspase-8 Acts in a Non-enzymatic Role as a Scaffold for Assembly of a Pro-inflammatory FADDosome Complex upon TRAIL Stimulation Mol. Cell, 2017-02-16;65(4):715-729.e5. 2017-02-16 [PMID: 28212752] (Human)
• Serum from Varicose Patients Induces Senescence-Related Dysfunction of Vascular Endothelium Generating Local and Systemic Proinflammatory Conditions Oxid Med Cell Longev, 2016-11-23;2016(0):2069290. 2016-11-23 [PMID: 27994710] (Human)
• Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide Sci Rep, 2016-05-17;6(0):26071. 2016-05-17 [PMID: 27184415] (Human)
• Zhao , Yanfeng, Zhu , Li, Zhou , Tong, Zhang , Qingxian, Shi , Sufang, Liu , Lijun, Lv , Jicheng, Zhang , Hong Urinary CXCL1: a novel predictor of IgA nephropathy progression. PLoS ONE, 2015-03-27;10(3):e0119033. 2015-03-27 [PMID: 25816025] (Human)
• Kearney C, Cullen S, Tynan G, Henry C, Clancy D, Lavelle E, Martin S Necroptosis suppresses inflammation via termination of TNF- or LPS-induced cytokine and chemokine production. Cell Death Differ, 2015-01-23;22(8):1313-27. 2015-01-23 [PMID: 25613374] (Human)
• Schupp J, Binder H, Jager B, Cillis G, Zissel G, Muller-Quernheim J, Prasse A Macrophage activation in acute exacerbation of idiopathic pulmonary fibrosis. PLoS ONE, 2015-01-15;10(1):e0116775. 2015-01-15 [PMID: 25590613] (Human)
• Assirelli E, Pulsatelli L, Dolzani P, Platano D, Olivotto E, Filardo G, Trisolino G, Facchini A, Borzi R, Meliconi R Human osteoarthritic cartilage shows reduced in vivo expression of IL-4, a chondroprotective cytokine that differentially modulates IL-1beta-stimulated production of chemokines and matrix-degrading enzymes in vitro. PLoS ONE, 2014-05-12;9(5):e96925. 2014-05-12 [PMID: 24819779] (Human)
• Chen , Lianyu, Qu , Chao, Chen , Hao, Xu , Litao, Qi , Qi, Luo , Jianmin, Wang , Kun, Meng , Zhiqiang, Chen , Zhen, Wang , Peng, Liu , Luming Chinese herbal medicine suppresses invasion-promoting capacity of cancer-associated fibroblasts in pancreatic cancer. PLoS ONE, 2014-04-29;9(4):e96177. 2014-04-29 [PMID: 24781445] (Human)
• Shah S, King E, Chandrasekhar A, Newton R Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression by dexamethasone. J Biol Chem, 2014-04-01;289(19):13667-79. 2014-04-01 [PMID: 24692548] (Human)
• Lo H, Lai T, Li C, Wu W TNF-alpha induces CXCL1 chemokine expression and release in human vascular endothelial cells in vitro via two distinct signaling pathways. Acta Pharmacol Sin, 2014-02-03;35(3):339-50. 2014-02-03 [PMID: 24487964] (Human)
• Parola C, Salogni L, Vaira X, Scutera S, Somma P, Salvi V, Musso T, Tabbia G, Bardessono M, Pasquali C, Mantovani A, Sozzani S, Bosisio D Selective activation of human dendritic cells by OM-85 through a NF-kB and MAPK dependent pathway. PLoS ONE, 2013-12-30;8(12):e82867. 2013-12-30 [PMID: 24386121] (Human)
• Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients. Mucosal Immunol, 2011-12-21;5(2):140-9. 2011-12-21 [PMID: 22189956] (Human)
• Meen AJ, Oynebraten I, Reine TM, Duelli A, Svennevig K, Pejler G, Jenssen T, Kolset SO Serglycin is a major proteoglycan in polarized human endothelial cells and is implicated in the secretion of the chemokine GROalpha/CXCL1. J. Biol. Chem., 2010-11-12;286(4):2636-47. 2010-11-12 [PMID: 21075844] (Human)
• Kisand K, Boe Wolff AS, Podkrajsek KT, Tserel L, Link M, Kisand KV, Ersvaer E, Perheentupa J, Erichsen MM, Bratanic N, Meloni A, Cetani F, Perniola R, Ergun-Longmire B, Maclaren N, Krohn KJ, Pura M, Schalke B, Strobel P, Leite MI, Battelino T, Husebye ES, Peterson P, Willcox N, Meager A Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J. Exp. Med., 2010-02-01;207(2):299-308. 2010-02-01 [PMID: 20123959] (Human)
• Begley LA, Kasina S, Macdonald J, Macoska JA The inflammatory microenvironment of the aging prostate facilitates cellular proliferation and hypertrophy. Cytokine, 2008-06-24;43(2):194-9. 2008-06-24 [PMID: 18572414] (Human)
• Birrell MA, Catley MC, Hardaker E, Wong S, Willson TM, McCluskie K, Leonard T, Farrow SN, Collins JL, Haj-Yahia S, Belvisi MG Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses. J. Biol. Chem., 2007-08-31;282(44):31882-90. 2007-08-31 [PMID: 17766241] (Human)
• Birrell MA, Wong S, Catley MC, Belvisi MG Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages. J. Cell. Physiol., 2008-01-01;214(1):27-37. 2008-01-01 [PMID: 17541958] (Human)
• Birrell MA, Wong S, Dekkak A, De Alba J, Haj-Yahia S, Belvisi MG Role of matrix metalloproteinases in the inflammatory response in human airway cell-based assays and in rodent models of airway disease. J. Pharmacol. Exp. Ther., 2006-05-11;318(2):741-50. 2006-05-11 [PMID: 16690722] (Human)
• Wunder DM, Mueller MD, Birkhauser MH, Bersinger NA Increased ENA-78 in the follicular fluid of patients with endometriosis. Acta Obstet Gynecol Scand, 2006-01-01;85(3):336-42. 2006-01-01 [PMID: 16553183] (Human)
• Oynebraten I, Bakke O, Brandtzaeg P, Johansen FE, Haraldsen G Rapid chemokine secretion from endothelial cells originates from 2 distinct compartments. Blood, 2004-03-25;104(2):314-20. 2004-03-25 [PMID: 15044249] (Human)

FAQs for CXCL1/GRO alpha/KC/CINC-1 (DY275). (Showing 1 - 1 of 1 FAQs).

1. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: CXCL1