Human Complement Component C5a DuoSet ELISA, 15 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human Complement Component C5a DuoSet ELISA, 15 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: C5

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human Complement Component C5a DuoSet ELISA, 15 Plate

• C5
• C5A
• Complement Component C5a
• HE

Background

Human complement 5a (C5a) is an enzymatically generated glycoprotein that belongs to a family of structurally and functionally related proteins known as anaphylatoxins. C5a is a 74 amino acid (aa) peptide that is created by the activity of C5a convertase on the C5 alpha-chain. Human C5a has four alpha-helices plus three intrachain disulfide bonds that create a triple loop structure.

Publications for Complement Component C5a (DY2037)(29)

Publications using DY2037

• Senent, Y;Remírez, A;Repáraz, D;Llopiz, D;Celias, DP;Sainz, C;Entrialgo-Cadierno, R;Suarez, L;Rouzaut, A;Alignani, D;Tavira, B;Lambris, JD;Woodruff, TM;de Andrea, CE;Ruffell, B;Sarobe, P;Ajona, D;Pio, R; The C5a/C5aR1 axis promotes migration of tolerogenic dendritic cells to lymph nodes, impairing the anticancer immune response Cancer immunology research 2024-12-12 [PMID: 39666368] (Mouse)
• Bekirian, C;Valsecchi, I;Bachellier-Bassi, S;Scandola, C;Guijarro, JI;Chauvel, M;Mourer, T;Gow, NAR;Aimanianda, VK;d'Enfert, C;Fontaine, T; ?-1,6-Glucan plays a central role in the structure and remodeling of the bilaminate fungal cell wall eLife 2024-12-05 [PMID: 39636210] (Human)
• Chick, HM;Rees, ME;Lewis, ML;Williams, LK;Bodger, O;Harris, LG;Rushton, S;Wilkinson, TS; Using the Traditional Ex Vivo Whole Blood Model to Discriminate Bacteria by Their Inducible Host Responses Biomedicines 2024-03-25 [PMID: 38672079] (Human)
• Budding, K;Bos, JW;Dijkxhoorn, K;de Zeeuw, E;Bloemenkamp, LM;Zekveld, EM;Groen, EJN;Jacobs, BC;Huizinga, R;Goedee, HS;Cats, EA;Leusen, JHW;van den Berg, LH;Hack, CE;van der Pol, WL; IgM anti-GM2 antibodies in patients with multifocal motor neuropathy target Schwann cells and are associated with early onset Journal of neuroinflammation 2024-04-17 [PMID: 38632654] (Human)
• Park, SY;Eum, DY;Jin, Y;Lee, CY;Shim, JW;Choi, SH;Park, SJ;Heo, K;Choi, YJ; Downregulation of complement factor H attenuates the stemness of MDA?MB?231 breast cancer cells via modulation of the ERK and p38 signaling pathways Oncology letters 2023-12-01 [PMID: 37927420] (Human)
• Sereti, I;Verburgh, ML;Gifford, J;Lo, A;Boyd, A;Verheij, E;Verhoeven, A;Wit, FWNM;Schim van der Loeff, MF;Giera, M;Kootstra, NA;Reiss, P;Vujkovic-Cvijin, I; Impaired gut microbiota-mediated short-chain fatty acid production precedes morbidity and mortality in people with HIV Cell reports 2023-10-30 [PMID: 37918403] (Human)
• Struijf, EM;De la O Becerra, KI;Ruyken, M;de Haas, CJC;van Oosterom, F;Siere, DY;van Keulen, JE;Heesterbeek, DAC;Dolk, E;Heukers, R;Bardoel, BW;Gros, P;Rooijakkers, SHM; Inhibition of cleavage of human complement component C5 and the R885H C5 variant by two distinct high affinity anti-C5 nanobodies The Journal of biological chemistry 2023-06-23 [PMID: 37356719] (Human)
• DJ Doorduijn, MV Lukassen, MFL van 't Wou, V Franc, M Ruyken, BW Bardoel, AJR Heck, SHM Rooijakker Soluble MAC is primarily released from MAC-resistant bacteria that potently convert complement component C5 Elife, 2022-08-10;11(0):. 2022-08-10 [PMID: 35947526] (Human)
• XR Lim, JWL Tan, GYL Chan, J Hou, L Xie, VHL Goh, J Boon, SSM Lee, CM Teo, SC Tan, KP Leong, BYH Thong, BPL Leung Evaluation of Patients with Vaccine Allergies Prior to mRNA-Based COVID-19 Vaccination Vaccines, 2022-06-27;10(7):. 2022-06-27 [PMID: 35891189] (Human)
• P Ding, Y Xu, L Li, X Lv, L Li, J Chen, D Zhou, X Wang, Q Wang, W Zhang, T Liao, QH Ji, QY Lei, W Hu Intracellular complement C5a/C5aR1 stabilizes beta-catenin to promote colorectal tumorigenesis Cell Reports, 2022-05-31;39(9):110851. 2022-05-31 [PMID: 35649359] (Human)
• MAG Sage, KD Cranmer, ML Semeraro, S Ma, EV Galkina, Y Tran, KL Wycoff, JA Sharp A Factor H-Fc fusion protein increases complement-mediated opsonophagocytosis and killing of community associated methicillin-resistant Staphylococcus aureus PLoS ONE, 2022-03-24;17(3):e0265774. 2022-03-24 [PMID: 35324969] (Human)
• TA Shah, HK Pallera, CL Kaszowski, WT Bass, FA Lattanzio Therapeutic Hypothermia Inhibits the Classical Complement Pathway in a Rat Model of Neonatal Hypoxic-Ischemic Encephalopathy Frontiers in Neuroscience, 2021-02-12;15(0):616734. 2021-02-12 [PMID: 33642979] (Rat)
• H Gunawardan, T Romero, N Yao, S Heidt, A Mulder, DA Elashoff, NM Valenzuela Tissue-specific endothelial cell heterogeneity contributes to unequal inflammatory responses Scientific Reports, 2021-01-21;11(1):1949. 2021-01-21 [PMID: 33479269] (Human)
• A Mahajan, L Hasíková, U Hampel, A Grüneboom, X Shan, I Herrmann, F Garreis, F Bock, J Knopf, J Singh, C Schauer, S Mahajan, M Leppkes, F Paulsen, U Schlötzer-, V Krenn, A Jünemann, B Hohberger, G Schett, M Herrmann, LE Muñoz Aggregated neutrophil extracellular traps occlude Meibomian glands during ocular surface inflammation The ocular surface, 2021-01-02;20(0):1-12. 2021-01-02 [PMID: 33401018] (Human)
• K Balázs, E Kis, C Badie, EN Bogdándi, S Candéias, LC Garcia, I Dominczyk, B Frey, U Gaipl, Z Jurányi, ZS Kocsis, EA Rutten, G Sáfrány, P Widlak, K Lumniczky Radiotherapy-Induced Changes in the Systemic Immune and Inflammation Parameters of Head and Neck Cancer Patients Cancers (Basel), 2019-09-06;11(9):. 2019-09-06 [PMID: 31500214] (Human)
• A Mahajan, A Grüneboom, L Petru, MJ Podolska, L Kling, C Maueröder, F Dahms, S Christians, L Günter, V Krenn, A Jünemann, F Bock, C Schauer, G Schett, B Hohberger, M Herrmann, LE Muñoz Frontline Science: Aggregated neutrophil extracellular traps prevent inflammation on the neutrophil-rich ocular surface J. Leukoc. Biol., 2019-04-12;0(0):. 2019-04-12 [PMID: 30977943] (Human)
• R Sfriso, S Zhang, CA Bichsel, O Steck, A Despont, OT Guenat, R Rieben 3D artificial round section micro-vessels to investigate endothelial cells under physiological flow conditions Sci Rep, 2018-04-12;8(1):5898. 2018-04-12 [PMID: 29651108] (Human)
• MC Gruda, KG Ruggeberg, P O'Sullivan, T Guliashvil, AR Scheirer, TD Golobish, VJ Capponi, PP Chan Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorb� sorbent porous polymer beads PLoS ONE, 2018-01-25;13(1):e0191676. 2018-01-25 [PMID: 29370247] (Human)
• AK Bongoni, E Salvaris, S Nordling, N Klymiuk, E Wolf, DL Ayares, R Rieben, PU Magnusson, PJ Cowan Surface modification of pig endothelial cells with a branched heparin conjugate improves their compatibility with human blood Sci Rep, 2017-06-30;7(1):4450. 2017-06-30 [PMID: 28667310] (Human)
• C Lood, S Arve, J Ledbetter, KB Elkon TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA J. Exp. Med., 2017-06-12;0(0):. 2017-06-12 [PMID: 28606989] (Human)
• PS Hair, LA Sass, T Vazifedan, TA Shah, NK Krishna, KM Cunnion Complement effectors, C5a and C3a, in cystic fibrosis lung fluid correlate with disease severity PLoS ONE, 2017-03-09;12(3):e0173257. 2017-03-09 [PMID: 28278205] (Human)
• W B?ogowski, E Zuba-Surma, D Sa?ata, M Budkowska, B Do??gowska, T Starzy?ska Peripheral trafficking of bone-marrow-derived stem cells in patients with different types of gastric neoplasms Oncoimmunology, 2015-10-29;5(4):e1099798. 2015-10-29 [PMID: 27141380] (Human)
• McDonald C, Darling A, Conroy A, Tran V, Cabrera A, Liles W, Wang M, Aboud S, Urassa W, Fawzi W, Kain K Inflammatory and Angiogenic Factors at Mid-Pregnancy Are Associated with Spontaneous Preterm Birth in a Cohort of Tanzanian Women. PLoS ONE, 2015-08-06;10(8):e0134619. 2015-08-06 [PMID: 26247200] (Human)
• Smailhodzic D, van Asten F, Blom A, Mohlin F, den Hollander A, van de Ven J, van Huet R, Groenewoud J, Tian Y, Berendschot T, Lechanteur Y, Fauser S, de Bruijn C, Daha M, van der Wilt G, Hoyng C, Klevering B Zinc supplementation inhibits complement activation in age-related macular degeneration. PLoS ONE, 2014-11-13;9(11):e112682. 2014-11-13 [PMID: 25393287] (Human)
• Shah T, Mauriello C, Hair P, Sandhu A, Stolz M, Bass W, Krishna N, Cunnion K Clinical hypothermia temperatures increase complement activation and cell destruction via the classical pathway. J Transl Med, 2014-06-24;12(0):181. 2014-06-24 [PMID: 24962100] (Human)
• Chmilewsky F, Jeanneau C, Laurent P, About I Pulp fibroblasts synthesize functional complement proteins involved in initiating dentin-pulp regeneration. Am J Pathol, 2014-05-09;184(7):1991-2000. 2014-05-09 [PMID: 24814102] (Human)
• Conroy A, Gelvez M, Hawkes M, Rajwans N, Liles W, Villar-Centeno L, Kain K Host biomarkers distinguish dengue from leptospirosis in Colombia: a case-control study. BMC Infect Dis, 2014-01-20;14(0):35. 2014-01-20 [PMID: 24444080] (Human)
• Schilder L, Nurmohamed S, ter Wee P, Paauw N, Girbes A, Beishuizen A, Beelen R, Groeneveld A Citrate confers less filter-induced complement activation and neutrophil degranulation than heparin when used for anticoagulation during continuous venovenous haemofiltration in critically ill patients. BMC Nephrol, 2014-01-17;15(0):19. 2014-01-17 [PMID: 24438360] (Human)
• Sharp JA, Echague CG, Hair PS Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tactic. PLoS ONE, 2012-05-31;7(5):e38407. 2012-05-31 [PMID: 22675461] (Human)

Bioinformatics

• Gene Symbol: C5