Human alpha-Synuclein DuoSet ELISA, 5 Plate

• Reactivity: Hu
• Applications: ELISA
• Conjugate: Biotin

Human alpha-Synuclein DuoSet ELISA, 5 Plate Summary

• Source: N/A
• Assay Type: Solid Phase Sandwich ELISA
• Inter-Assay: See PDF Datasheet for details
• Intra-Assay: See PDF Datasheet for details
• Spike Recovery: See PDF Datasheet for details
• Sample Volume: See PDF Datasheet for details
• Gene: SNCA

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: No significant interference observed with available related molecules.

Packaging, Storage & Formulations

• Storage: Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Human alpha-Synuclein DuoSet ELISA, 5 Plate

• alpha-Synuclein
• I+/--synuclein
• MGC110988
• NACP
• non A-beta component of AD amyloid
• Non-A beta component of AD amyloid
• Non-A4 component of amyloid precursor
• PARK1
• PARK4
• PD1
• SNCA
• synuclein alpha-140
• synuclein, alpha (non A4 component of amyloid precursor)
• Synuclein-alpha
• truncated alpha synuclein

Background

The synuclein family includes alpha-Synuclein, beta-Synuclein, gamma-Synuclein, and synoretin. These small, highly conserved proteins are localized predominantly in the brain, concentrated in presynaptic nerve terminals. Alpha-Synuclein is normally a soluble protein. Abnormal alpha-synuclein forms filamentous inclusions (Lewy bodies and Lewy neurites) in several neurodegenerative diseases, including Parkinson's disease (PD), dementia with Lewy bodies, and Alzheimer's disease. Beta-Synuclein and gamma-Synuclein (synoretin) associate with alpha-synuclein and inhibit its aggregation.

Publications for alpha-Synuclein (DY1338-05)(2)

Publications using DY1338-05

• Oliveras-Cañellas, N;Castells-Nobau, A;de la Vega-Correa, L;Latorre-Luque, J;Motger-Albertí, A;Arnoriaga-Rodriguez, M;Garre-Olmo, J;Zapata-Tona, C;Coll-Martínez, C;Ramió-Torrentà, L;Moreno-Navarrete, JM;Puig, J;Villarroya, F;Ramos, R;Casadó-Anguera, V;Martín-García, E;Maldonado, R;Mayneris-Perxachs, J;Fernández-Real, JM; Adipose tissue coregulates cognitive function Science advances 2023-08-11 [PMID: 37566655] (Human)
• J Li, J Zhao, L Chen, H Gao, J Zhang, D Wang, Y Zou, Q Qin, Y Qu, J Li, Y Xiong, Z Min, M Yan, Z Mao, Z Xue alpha-Synuclein induces Th17 differentiation and impairs the function and stability of Tregs by promoting RORC transcription in Parkinson's disease Brain, Behavior, and Immunity, 2022-11-04;0(0):. 2022-11-04 [PMID: 36343753] (Mouse, Transgenic Mouse)

FAQs for alpha-Synuclein (DY1338-05). (Showing 1 - 2 of 2 FAQs).

1. I'm looking for an alpha-Synuclein antibody with an epitope located in the first half (N-terminus) of the protein - preferably a monoclonal antibody. Can you help me with that?
   • Please take a look at NB110-57475. It has been validated for human, rat and mouse and the applications ICC and WB and the epitope it detects is in the N terminal.
2. What is the difference between the Quantikine and Duoset ELISA kits?
   • Our Quantikine kits are fully optimized and validated for the sample types listed on the product specific webpage and datasheet, as this can vary between kits. Each kit is supplied ready to use with one pre-coated 96-well plate, a detection antibody directly conjugated to HRP, and all other necessary reagents. These kits are ideal for researchers who want the convenience of a ready to use and optimized ELISA product. Some of these kits are also available prepackaged in larger 6 and 50 plate sizes.Our DuoSet Kits, in contrast, are ELISA development kits containing the capture and detection antibody, the mass-value calibrated standard, and streptavidin-HRP to prepare approximately 5 or 15 plates. Ancillary reagents will need to be used/purchased, and for most kits, we will recommend one of our Ancillary Reagent Kits, which contain the reagents we use ourselves in-house. DuoSet kits are validated only for cell culture supernatant samples and therefore require further development and validation for accurate measurement in more complex samples such as serum and plasma. Our DuoSet Kits offer an economical, flexible alternative for the experienced ELISA user.

Bioinformatics

• Gene Symbol: SNCA