alpha Synuclein

Interleukin 6 (IL-6) - I can change your body's temperature set point!

IL-6 is an immunoregulatory cytokine that functions in inflammation and B-cell maturation. It was originally identified as a B-cell differentiation factor. It is primarily made at sites of acute and chronic inflammation, where it is secreted into serum and induces a transcriptional inflammatory response through the cell surface assembly of interleukin-6 alpha receptor (IL-6R, alpha) and the signaling receptor gp130.

Understanding Neurodegeneration through Alpha Synuclein and Synucleinopathies

Alpha-synuclein is an abundant presynaptic protein expressed predominantly in brain, concentrated in presynaptic nerve terminals. Alpha-synuclein is deposited as fibrillary aggregates in neurons or glial cells which is a hallmark lesion in a subset of neurodegenerative disorders including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (all collectively referred to as synucleinopathies).

Alpha-Synuclein: A Possibility for Early Diagnosis of Parkison's Disease

In the UK, 127,000 people are affected by the progressive neurodegenerative condition Parkinson's disease. Parkinson's is extremely difficult to diagnose in its early stages. The current method of diagnosis includes examination for physical signs of Parkinson's along with a detailed history of symptoms. The defining neuropathological characteristics of Parkinson's disease is Lewy bodies.