Recombinant Human HSD17B8 Protein

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SDS-Page: Recombinant Human HSD17B8 Protein [NBP1-51071] - 15 % SDS-PAGE (3ug)

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
0.5 mg/ml

Order Details

Recombinant Human HSD17B8 Protein Summary

Description
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-261 of Human HSD17B8

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MASQLQNRLR SALALVTGAG SGIGRAVSVR LAGEGATVAA CDLDRAAAQE TVRLLGGPGS KEGPPRGNHA AFQADVSEAR AARCLLEQVQ ACFSRPPSVV VSCAGITQDE FLLHMSEDDW DKVIAVNLKG TFLVTQAAAQ ALVSNGCRGS IINISSIVGK VGNVGQTNYA ASKAGVIGLT QTAARELGRH GIRCNSVLPG FIATPMTQKV PQKVVDKITE MIPMGHLGDP EDVADVVAFL ASEDSGYITG TSVEVTGGLF M

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
HSD17B8
Purity
>95% pure by SDS-PAGE

Applications/Dilutions

Theoretical MW
29.1 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Tris-HCl buffer (pH8.0) containing 40% glycerol, 150mM NaCl
Preservative
No Preservative
Concentration
0.5 mg/ml
Purity
>95% pure by SDS-PAGE

Alternate Names for Recombinant Human HSD17B8 Protein

  • D6S2245EdJ1033B10.9
  • EC 1.1.1.-
  • EC 1.1.1.62
  • EC 1.1.1.63,17-beta-HSD 8
  • estrogen 17-oxidoreductase
  • FABGLestradiol 17-beta-dehydrogenase 8
  • H2-KE6
  • HKE6FabG (beta-ketoacyl-[acyl-carrier-protein] reductase, E coli) like (E. coli)
  • hydroxysteroid (17-beta) dehydrogenase 8,3-oxoacyl-[acyl-carrier-protein] reductase
  • KE6
  • ke-6
  • Ke-6,17-beta-hydroxysteroid dehydrogenase 8
  • Protein Ke6
  • Really interesting new gene 2 protein
  • RING2FABG
  • SDR30C1
  • short chain dehydrogenase/reductase family 30C, member 1
  • Testosterone 17-beta-dehydrogenase 8

Background

HSD17B8, also known as estradiol 17-beta-dehydrogenase 8, belongs to the short-chain dehydrogenases/reductases (SDR) family. In mice, the Ke6 protein is a 17-beta-hydroxysteroid dehydrogenase that can regulate the concentration of biologically active estrogens and androgens. It is preferentially an oxidative enzyme and inactivates estradiol, testosterone, and dihydrotestosterone. However, the enzyme has some reductive activity and can synthesize estradiol from estrone. It may play a role in biosynthesis of fatty acids in mitochondria. Recombinant human HSD17B8 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol HSD17B8