Recombinant Human HOP Protein

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
1 mg/ml

Order Details

Recombinant Human HOP Protein Summary

Description
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-73 of Human HOP

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MGSHMSAETA SGPTEDQVEI LEYNFNKVDK HPDSTTLCLI AAEAGLSEEE TQKWFKQRLA KWRRSEGLPS ECRSVTD

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
HOPX
Purity
>90%, by SDS-PAGE

Applications/Dilutions

Theoretical MW
10.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.
Buffer
20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
Preservative
No Preservative
Concentration
1 mg/ml
Purity
>90%, by SDS-PAGE

Alternate Names for Recombinant Human HOP Protein

  • CAMEO
  • HOD
  • homeodomain-only protein
  • HOP homeobox
  • HOPLAGYNECC1OB1SMAP31
  • Lung cancer-associated Y protein
  • MGC20820
  • not expressed in choriocarcinoma clone 1
  • Not expressed in choriocarcinoma protein 1
  • odd homeobox 1 protein
  • Odd homeobox protein 1
  • TOTO

Background

HOPX, also known as homeodomain-only protein, acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. This protein prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy. Recombinant human HOPX protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol HOPX