HOP Products

Antibodies
HOP Antibody (DS14F5)
HOP Antibody (DS14F5)
NBP1-97503
Species: Hu, Mu, Rt, Po, Bv, Ca, Ch, GP, Md, Pm, Rb, Sh, Xp
Applications: WB, IHC, IHC-P, IP
Host: Mouse Monoclonal
HOP Antibody
HOP Antibody
NBP1-92003
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
HOP Antibody (3D6)
HOP Antibody (3D6)
H00084525-M01
Species: Hu
Applications: WB, ELISA
Host: Mouse Monoclonal
Lysates
HOP Overexpression Lysate (De ...
HOP Overexpression Lysate (Denatured)
H00084525-T01
Species: Hu
Applications: WB
HOP Overexpression Lysate (Na ...
HOP Overexpression Lysate (Native)
NBP2-05585
Applications: WB
HOP Overexpression Lysate (Na ...
HOP Overexpression Lysate (Native)
NBP2-05584
Applications: WB
Proteins
HOP Recombinant Protein Antig ...
HOP Recombinant Protein Antigen
NBP1-92003PEP
Species: Hu
Applications: AC
HOP Recombinant Protein
HOP Recombinant Protein
NBP1-98893
Species: Hu
Applications: PAGE
RNAi
HOP RNAi
HOP RNAi
H00084525-R03
Species: Hu
Applications: RNAi, RNAi SP
HOP RNAi
HOP RNAi
H00084525-R01
Species: Hu
Applications: RNAi, RNAi SP
HOP RNAi
HOP RNAi
H00084525-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

HOP, also known as Homeodomain-only protein, has a 73 amino acid short isoform that is 8 kDa and a long 94 amino acid isoform that is 10 kDa; nucleus located; widely expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen; may interact with serum response factor (SRF) and modulate SRF-dependent cardiac-specific gene expression and cardiac development; prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF; overexpression causes cardiac hypertrophy; and may also act as a tumor suppressor. Disease research is currently being studied with relation to choriocarcinoma, abdominal actinomycosis, nevus of ota, actinomycosis, lung cancer, nevus, carcinoma, squamous cell carcinoma, oral squamous cell carcinoma, esophageal squamous cell carcinoma, dilated cardiomyopathy, thyroid carcinoma, endometrial cancer, cardiomyopathy, gastric cancer, glioblastoma, esophagitis, and thyroiditis. This protein has shown an interaction with HDAC2, EPC1, SRF, GZMB, HOXB9, TLX3, and ZSCAN1 in the negative regulation of transcription from RNA polymerase II promoter, trophectodermal cell differentiation, transcription, DNA-dependent, regulation of transcription, DNA-dependent, and multicellular organismal development pathways.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 84525
Alternate Names
  • odd homeobox 1 protein
  • CAMEO
  • not expressed in choriocarcinoma clone 1
  • HOD
  • homeodomain-only protein
  • Odd homeobox protein 1
  • TOTO
  • Not expressed in choriocarcinoma protein 1
  • Lung cancer-associated Y protein
  • HOPLAGYNECC1OB1SMAP31
  • MGC20820
  • HOP homeobox

PTMs for HOP

Learn more about PTMs related to HOP.

Methylation
Demethylation
Deacetylation
Acetylation

Bioinformatics Tool for HOP

Discover related pathways, diseases and genes to HOP. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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