HMGA1 Antibody

Images

 
Western Blot: HMGA1 Antibody [NB100-56468] - Analysis of HMGA1 in the 1) absence and 2) presence of immunizing peptide in human pancreas lysate using this antibody at 1 ug/ml.
Immunohistochemistry-Paraffin: HMGA1 Antibody [NB100-56468] - Staining of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ...read more

Product Details

Summary
Reactivity Hu, Mu, Rt, Po, Ca, BvSpecies Glossary
Applications WB, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

HMGA1 Antibody Summary

Immunogen
A synthetic peptide (DGTEKRGRGRPRKQ) corresponding to amino acids 19-32 of human HMGA1 was used as immunogen.
Specificity
The amino acid sequence used as immunogen is 100% homologous in human, dog, mouse, rat, pig, 92% homologous in bovine and 84% homologous in chicken.
Predicted Species
Bovine (92%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
HMGA1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-3 ug/ml
  • Immunohistochemistry-Paraffin 1:10-1:500
Positive Control
Pancreas Lysate (NB820-59244)
HMGA1 Lysate (NBL1-11609)
Control Peptide
HMGA1 Peptide (NB100-56468PEP)

Reactivity Notes

Predicted to react with Bovine and Chicken.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS containing 0.05% BSA
Preservative
0.05% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for HMGA1 Antibody

  • high mobility group AT-hook 1
  • High mobility group AT-hook protein 1
  • High mobility group protein A1
  • high mobility group protein HMG-I/HMG-Y
  • High mobility group protein R
  • high-mobility group (nonhistone chromosomal) protein isoforms I and Y
  • HMGA1A
  • HMG-I(Y)
  • HMGIYMGC12816
  • HMG-R
  • MGC4242
  • MGC4854
  • nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y

Background

DNA-binding non-histone nuclear protein, is a key member of HMGA protein family. It consists of a highly conserved AT-hook DNA-binding domain that mediates binding to AT-rich sequences in the minor groove of chromosomal DNA. It functions as architectural chromatin-binding transcription factor altering the conformation of DNA by modulating nuclear protein-DNA complexes. It is involved in many cellular processes including growth regulation, viral induction of beta-IFN gene and regulation of inducible gene transcription. It also physically interacts with transcription factors such as AP-1, Sp-1 and CAAT/enhancer binding protein-beta to modulate their ability to activate gene expression. It functions as a direct transcriptional target of c-Jun and c-Myc and is maximally expressed during embryonic development. Pathological role of HMGA1 include integration of retroviruses into chromosomes and enhancing metastasis of tumor cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol HMGA1
Entrez
Uniprot