HMBS Antibody

Western Blot: HMBS Antibody [H00003145-D01P] - Analysis of HMBS expression in transfected 293T cell line by HMBS polyclonal antibody.Lane 1: HMBS transfected lysate(39.30 KDa).Lane 2: Non-transfected lysate.

Immunocytochemistry/Immunofluorescence: HMBS Antibody [H00003145-D01P] - Analysis of antibody to HMBS on HeLa cell. Antibody concentration 10 ug/ml.

Product Discontinued

HMBS Antibody Summary

• Description: Quality control test: Antibody reactive against mammalian transfected lysate.
• Immunogen: HMBS (NP_000181.2, 1 a.a. - 361 a.a.) full-length human protein. MSGNGNAAATAEENSPKMRVIRVGTRKSQLARIQTDSVVATLKASYPGLQFEIIAMSTTGDKILDTALSKIGEKSLFTKELEHALEKNEVDLVVHSLKDLPTVLPPGFTIGAICKRENPHDAVVFHPKFVGKTLETLPEKSVVGTSSLRRAAQLQRKFPHLEFRSIRGNLNTRLRKLDEQQEFSAIILATAGLQRMGWHNRVGQILHPEECMYAVGQGALGVEVRAKDQDILDLVGVLHDPETLLRCIAERAFLRHLEGGCSVPVAVHTAMKDGQLYLTGGVWSLDGSDSIQETMQATIHVPAQHEDGPEDDPQLVGITARNIPRGPQLAAQNLGISLANLLLSKGAKNILDVARQLNDAH
• Specificity: HMBS - hydroxymethylbilane synthase,
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HMBS
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB and also on transfected lysate in WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for HMBS Antibody

• hydroxymethylbilane synthasePre-uroporphyrinogen synthase
• PBGDPBG-D
• PORC
• porphobilinogen deaminase
• porphyria, acute; Chester type
• UPSEC 2.5.1.61
• uroporphyrinogen I synthase
• uroporphyrinogen I synthetase

Background

This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for HMBS Antibody (H00003145-D01P)(1)

Publication using H00003145-D01P

• Anand S, Wilson C, Hasan T, Maytin EV. Vitamin D3 enhances the apoptotic response of epithelial tumors to aminolevulinate-based photodynamic therapy. Cancer Res. 2011-08-01 [PMID: 21807844]

Bioinformatics

• Gene Symbol: HMBS
• Entrez:
  • 3145(Human)
• Uniprot:
  • NP_000181.2(Human)