HLA-DR Antibody (L203) [PerCP (Peridinin-chlorophyll Protein Complex)]

Human peripheral blood lymphocytes were stained with (A) Mouse Anti-Human HLA-DR PerCP-conjugated Monoclonal Antibody (Catalog # FAB4869C) or (B) isotype control antibody (Catalog # IC002C) and Mouse anti-Human CD19 CFS-conjugated Monoclonal Antibody (Catalog # FAB4867F). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: L203
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PerCP (Peridinin-chlorophyll Protein Complex)

HLA-DR Antibody (L203) [PerCP (Peridinin-chlorophyll Protein Complex)] Summary

• Immunogen: RPMI 8866 human lymphoblastoid cells
  Accession # P01903
• Specificity: Detects human HLA‑DR.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: HLA-DRA
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for HLA-DR Antibody (L203) [PerCP (Peridinin-chlorophyll Protein Complex)]

• FLJ51114
• histocompatibility antigen HLA-DR alpha
• HLA class II histocompatibility antigen, DR alpha chain
• HLADR
• HLA-DR
• HLA-DRA
• HLA-DRA1
• major histocompatibility complex, class II, DR alpha
• MHC cell surface glycoprotein
• MHC class II antigen DRA
• MHC Class II DR
• MLRW

Background

HLA-DR is a transmembrane human major histocompatibility complex 2 (MHC II) family member and consists of a 34 kDa (alpha) subunit and one of several 28 kDa (beta) subunits. HLA-DR is expressed primarily by B cells and dendritic cells (DC), in which it binds peptides derived from internalized and processed antigenic proteins. It presents these peptides on the cell surface for recognition by the T cell receptor on CD4⁺ T cells. This interaction is central to antigen specificity in the adaptive immune response. HLA-DR alleles, polymorphisms, and aberrant expression are linked to a variety of diseases including autoimmunity and cancer.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for HLA-DR Antibody (FAB4869C)(5)

Publications using FAB4869C

• Friebel, J;Wegner, M;Blöbaum, L;Schencke, PA;Jakobs, K;Puccini, M;Ghanbari, E;Lammel, S;Thevathasan, T;Moos, V;Witkowski, M;Landmesser, U;Rauch-Kröhnert, U; Characterization of Biomarkers of Thrombo-Inflammation in Patients with First-Diagnosed Atrial Fibrillation International journal of molecular sciences 2024-04-08 [PMID: 38612918] (Flow Cytometry, Human)
• M Beki?, M Vasiljevi?, D Stojanovi?, V Kokol, D Mihajlovi?, D Vu?evi?, P Uskokovi?, M ?oli?, S Tomi? Phosphonate-Modified Cellulose Nanocrystals Potentiate the Th1 Polarising Capacity of Monocyte-Derived Dendritic Cells via GABA-B Receptor International Journal of Nanomedicine, 2022-07-23;17(0):3191-3216. 2022-07-23 [PMID: 35909813] (Flow Cytometry, Human)
• Marinho C, Azeredo E, Torrentes-Carvalho A, Marins-Dos-Santos A, Kubelka C, de Souza L, Cunha R, de-Oliveira-Pinto L Down-regulation of complement receptors on the surface of host monocyte even as in vitro complement pathway blocking interferes in dengue infection. PLoS ONE, 2014-07-25;9(7):e102014. 2014-07-25 [PMID: 25061945] (Flow Cytometry, Human)
• Schwenk , Robert, Banania , Glenna, Epstein , Judy, Kim , Yohan, Peters , Bjoern, Belmonte , Maria, Ganeshan , Harini, Huang , Jun, Reyes , Sharina, Stryhn , Anette, Ockenhouse , Christia, Buus , Soren, Richie , Thomas L, Sedegah , Martha Ex vivo tetramer staining and cell surface phenotyping for early activation markers CD38 and HLA-DR to enumerate and characterize malaria antigen-specific CD8+ T-cells induced in human volunteers immunized with a Plasmodium falciparum adenovirus-vectored malaria vaccine expressing AMA1. Malar J, 2013-10-29;12(0):376. 2013-10-29 [PMID: 24168370] (Flow Cytometry, Human)
• Sapkota B, Hill C, Pollack B Vemurafenib enhances MHC induction in BRAF homozygous melanoma cells. Oncoimmunology, 2013-01-01;2(1):e22890. 2013-01-01 [PMID: 23483066] (Flow Cytometry, Human)

Bioinformatics

• Gene Symbol: HLA-DRA
• Uniprot:
  • P01903()