HLA DQA2 Antibody Summary
Immunogen |
Peptide with sequence C-QSHGPSGQYTH corresponding to internal region according to NP_064440.1. |
Epitope |
C-QSHGPSGQYTH |
Isotype |
IgG |
Clonality |
Polyclonal |
Host |
Goat |
Gene |
HLA-DQA2 |
Purity |
Immunogen affinity purified |
Innovator's Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase. |
Applications/Dilutions
Dilutions |
- Immunohistochemistry 0.1-0.3 ug/ml
- Immunohistochemistry-Paraffin
- Peptide ELISA Detection limit 1:16000
- Western Blot 0.1-0.3ug/ml
|
Application Notes |
Western blot: Approx 26kDa band observed in Human Bone Marrow lysates (calculated MW of 28.0kDa according to NP_064440.1). Primary incubation was 1 hour IHC: Paraffin embedded Human Spleen. |
Publications |
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Packaging, Storage & Formulations
Storage |
Store at -20C. Avoid freeze-thaw cycles. |
Buffer |
Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA |
Preservative |
0.02% Sodium Azide |
Concentration |
0.5 mg/ml |
Purity |
Immunogen affinity purified |
Notes
Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.
Alternate Names for HLA DQA2 Antibody
Background
The HLA-DQA2 gene encodes a 255 amino acid long, 28 kDA HLA class II histocompatibility antigen, DQ alpha 2 chain that functions in the peptide loading of MHC class II molecules. It does so by releasing the CLIP molecule from the peptide binding site. The HLA-DQA2 gene participates in cell adhesion molecules (CAMs), antigen processing and presentation, transport of MHC II:Ii complex along Golgi to TGN, the CDC42 pathway, and in G-protein signaling in N-RAS regulation pathways. It is known to interact with genes CD4 and HLA-DQB1. HLA-DQA2 is linked to osteoarthritis, celiac disease, diabetes, asthma, thyroiditis, childhood type dermatomyositis, graft vs. host disease, narcolepsy, and lupus.
Limitations
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are
guaranteed for 1 year from date of receipt.
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Publications for HLA DQA2 Antibody (NBP1-52186)(1)
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Secondary Antibodies
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