Species: Hu, Mu
Applications: WB, ELISA
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Description
The HLA-DQA2 gene encodes a 255 amino acid long, 28 kDA HLA class II histocompatibility antigen, DQ alpha 2 chain that functions in the peptide loading of MHC class II molecules. It does so by releasing the CLIP molecule from the peptide binding site. The HLA-DQA2 gene participates in cell adhesion molecules (CAMs), antigen processing and presentation, transport of MHC II:Ii complex along Golgi to TGN, the CDC42 pathway, and in G-protein signaling in N-RAS regulation pathways. It is known to interact with genes CD4 and HLA-DQB1. HLA-DQA2 is linked to osteoarthritis, celiac disease, diabetes, asthma, thyroiditis, childhood type dermatomyositis, graft vs. host disease, narcolepsy, and lupus.
Bioinformatics
| Product By Gene ID |
3118 |
| Alternate Names |
- DX alpha chain
- DX-ALPHA
- HLA class II histocompatibility antigen, DQ alpha 2 chain
- HLA class II histocompatibility antigen, DQ(6) alpha chain
- HLA-DQA1
- HLA-DXAMHC class II DQA2
- major histocompatibility complex, class II, DQ alpha 2
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