HLA DPB1 Antibody - BSA Free

Immunocytochemistry/Immunofluorescence: HLA DPB1 Antibody [NBP2-56722] - Staining of human cell line HEK 293 shows localization to nucleus & cell junctions. Antibody staining is shown in green.

• Reactivity: Hu
• Applications: ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free

HLA DPB1 Antibody - BSA Free Summary

• Immunogen: This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: ATPENYVYQLRQECYAFNGTQRFLE
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: HLA-DPB1
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 0.25-2 ug/ml
• Application Notes: ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
• Control Peptide:

  HLA DPB1 Recombinant Protein Antigen (NBP2-56722PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2) and 40% Glycerol
• Preservative: 0.02% Sodium Azide
• Purity: Affinity purified

Alternate Names for HLA DPB1 Antibody - BSA Free

• DP beta 1 chain
• DPB1
• HLA class II histocompatibility antigen, DP(W4) beta chain
• HLA DP14-beta chain
• HLA-DP histocompatibility type, beta-1 subunit
• HLA-DP1B
• HLA-DPB
• major histocompatibility complex class II HLA DPB1 protein
• major histocompatibility complex, class II, DP beta 1
• MHC class II antigen beta chain
• MHC class II antigen DP beta 1 chain
• MHC class II antigen DPB1
• MHC class II antigen DPbeta1
• MHC class II HLA-DP-beta
• MHC HLA DPB1

Background

HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HLA-DPB1