HIPK2 Antibody (493918) [Alexa Fluor™ Plus 647]

• Clone: 493918
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

HIPK2 Antibody (493918) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human HIPK2 in direct ELISAs.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for HIPK2 Antibody (493918) [Alexa Fluor™ Plus 647]

• DKFZp686K02111
• EC 2.7.11.1
• FLJ23711
• hHIPk2
• HIPK2
• homeodomain interacting protein kinase 2
• homeodomain-interacting protein kinase 2
• PRO0593
• Stank

Background

Homeodomain-interacting protein kinase-2 (HIPK2) is a serine/threonine kinase which interacts with transcription factors, including p53, CREB1, SMAD1, SMAD2, RUNX1 and others, and can act as a corepressor or coactivator depending on the transcription factor and subcellular localization.  Post-translational modifications control HIPK2 activity, including phosphorylation, small ubiquitin-like modifier modification, acetylation, and ubiquitination. HIPK2 regulation of cell proliferation makes it a key effector of proliferative diseases including cancer and kidney fibrosis. For example, HIPK2 can repress the proliferative Wnt-1/b-catenin pathway and HIF-1, promote apoptosis by activation of p53 and repression of delta Np63 alpha , MDM2 and CtBP, and its activity is enhanced by anti-cancer drugs such as cisplatin and etoposide.  HIPK2 oncorepession can be blocked by cytoplasmic localization, hypoxia, gene mutation and loss of heterozygosity.

 

(Saul VV and Schmitz ML, J Mol Med (Berl). 2013 Sep;91(9):1051-8.)  (Saul VV and Schmitz ML, J Mol Med (Berl). 2013 Sep;91(9):1051-8.)  (D'Orazi G, et al, J Exp Clin Cancer Res. 2012 Aug 13;31:63. )

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.