HGF R/c-MET [p Tyr1003] Antibody


Western Blot: c-Met [p Tyr1003] Antibody [NSB882] - 293T cell extracts transiently transfected with human c-Met were resolved by SDS-PAGE on 10% Tris-glycine gel and transferred to PVDF. Membranes, after blocking ...read more

Product Details

Reactivity HuSpecies Glossary
Applications WB
0.5 mg/ml

Order Details

HGF R/c-MET [p Tyr1003] Antibody Summary

Synthetic phosphopeptide derived from the region of c-Met that contains tyrosine 1003.
p Tyr1003
Type I membrane protein
Met (c-Met) [Tyr1003]
Immunogen affinity purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS [pH7.4] containing BSA (1 mg/mL)
0.05% Sodium Azide
0.5 mg/ml
Immunogen affinity purified


Application Notes
WB: Detects a band of approximately 145 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Reactivity Notes

Cross-reacts with Human. Expected to cross-react with Mouse (100% identity with immunogen), Rat (100% identity with immunogen) due to sequence homology. Not yet tested in other species.

Alternate Names for HGF R/c-MET [p Tyr1003] Antibody

  • AUTS9
  • cMET
  • c-MET
  • EC 2.7.10
  • EC
  • hepatocyte growth factor receptor
  • HGF receptor
  • HGF/SF receptor
  • HGFR
  • Met (c-Met)
  • met proto-oncogene (hepatocyte growth factor receptor)
  • met proto-oncogene tyrosine kinase
  • MET
  • oncogene MET
  • Proto-oncogene c-Met
  • RCCP2
  • Scatter factor receptor
  • SF receptor
  • Tyrosine-protein kinase Met


Binding of scatter factor (SF)/hepatocyte growth factor (HGF) to the c Met receptor tyrosine kinase (RTK) triggers receptor dimerization and phosphorylation on multiple residues within the juxtamembrane, catalytic core and cytoplasmic tail domains, thereby regulating receptor internalization, catalytic activity and multisubstrate docking. c Met contains three tyrosines (Tyr-xx- x-Tyr-Tyr motif) within the activation loop of the catalytic domain. This is also seen with the insulin receptor, insulin-like growth factor receptor (IGF1R) and nerve growth factor (NGF) receptors/Trks, for which phosphorylation of all three tyrosines is required for full activation. With c Met (and the related family member, RON) phosphorylation of Tyr1234 and Tyr1235 have been shown to be important in receptor activation. Activation of the c Met receptor results in binding and/or phosphorylation of many intracellular signaling proteins including multiple adaptor proteins (e.g., Grb2, Shc, Cbl, Crk, cortactin, paxillin, and GAB1), and a variety of other signal transducers (e.g., PI 3-kinase, FAK, Src, ERK1&2, JNK1&2, PLC gamma, and STAT3). Tyr1003 is a negative regulatory phosphorylation site of c Met.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies


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Contact Information

Product PDFs


Gene Symbol MET

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