HEXO Antibody (OTI1B3) [PerCP]

• Reactivity: Hu, Rt, Pm, Pm
• Applications: WB, Flow, IHC
• Clone: OTI1B3
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: PerCP

HEXO Antibody (OTI1B3) [PerCP] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Full length human recombinant protein of human ERI1(NP_699163) produced in HEK293T cell.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Gene: ERI1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP2-72312. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for HEXO Antibody (OTI1B3) [PerCP]

• 3' exoribonuclease
• 3'-5' exonuclease ERI1
• 3'EXO
• 3'HEXO
• EC 3.1
• enhanced RNAi three prime mRNA exonuclease homolog 1
• Eri-1 homolog
• exoribonuclease 1
• HEXO
• histone mRNA 3' end-specific exonuclease
• Histone mRNA 3'-end-specific exoribonuclease
• Histone mRNA 3'-exonuclease 1
• MGC35395
• Protein 3'hExo
• THEX1
• three prime histone mRNA exonuclease 1,3'-5' exoribonuclease 1
• three prime mRNA exonuclease 1

Background

HEXO is a 50-kD protein containing a SAP domain capable of recognizing AT-rich scaffold-attachment regions (SARs) in chromosomal DNA, and a exonuclease domain similar to those of DEDD exonuclease family members. HEXO is an RNA exonuclease that binds to the 3' end of histone mRNAs and probably degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. It is also able to degrade the 3' overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as a regulator of RNA interference (RNAi).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ERI1