Hematopoietic Prostaglandin D Synthase/HPGDS Antibody

Western Blot: Hematopoietic Prostaglandin D Synthase/HPGDS Antibody [H00027306-B01P] - Analysis of PGDS expression in transfected 293T cell line by PGDS polyclonal antibody. Lane 1: PGDS transfected lysate(21.89 KDa). Lane 2: Non-transfected lysate.

Product Discontinued

Hematopoietic Prostaglandin D Synthase/HPGDS Antibody Summary

• Immunogen: PGDS (NP_055300.1, 1 a.a. - 199 a.a.) full-length human protein. MPNYKLTYFNMRGRAEIIRYIFAYLDIQYEDHRIEQADWPEIKSTLPFGKIPILEVDGLTLHQSLAIARYLTKNTDLAGNTEMEQCHVDAIVDTLDDFMSCFPWAEKKQDVKEQMFNELLTYNAPHLMQDLDTYLGGREWLIGNSVTWADFYWEICSTTLLVFKPDLLDNHPRLVTLRKKVQAIPAVANWIKRRPQTKL
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: HPGDS
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: This antibody is useful for Western Blot, Functional

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein G purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Hematopoietic Prostaglandin D Synthase/HPGDS Antibody

• EC 2.5.1.18
• EC 5.3.99.2
• glutathione S-transferase sigma
• Glutathione S-transferase
• Glutathione-dependent PGD synthase
• Glutathione-requiring prostaglandin D synthase
• GST class-sigma
• GSTS
• GSTShematopoietic prostaglandin D2 synthase
• hematopoietic prostaglandin D synthase
• HPGDS
• H-PGDS
• PGDS
• PGDSglutathione-dependent PGD synthetase
• Prostaglandin-H2 D-isomerase
• PTGDS2

Background

Prostaglandin D synthase catalyzes the isomerization of PGH2 to produce PGD2. Prostaglandin D synthase induces sleep, regulates nociception, inhibits platelet aggregation, and acts as an allergic mediator. Two distinct types of PGD synthase have been identified, namely the lipocalin type enzyme (b-trace) and the hematopoietic enzyme. Lipocalin type prostaglandin D synthase is localized in the central nervous system and male genital organs of various mammals and the human heart. This enzyme has been identified as b-trace, which is a major protein in human cerebrospinal fluid. Hematopoietic prostaglandin D synthase is widely distributed in the peripheral tissues and is localized in the antigen-presenting cells, mast cells, and megakaryocytes. This enzyme, which requires glutathione for activity, belongs to the sigma-class of glutathione-S-transferases.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HPGDS
• Uniprot:
  • NP_055300.1(Human)