Gremlin 1 Antibody (30C14) [Alexa Fluor® 594]

Product Discontinued

Gremlin 1 Antibody (30C14) [Alexa Fluor® 594] Summary

• Immunogen: This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with mouse recombinant protein Gremlin. Rat monoclonal anti mouse Gremlin O70326.
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Rat
• Gene: GREM1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • ELISA
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Gremlin 1 Antibody (30C14) [Alexa Fluor® 594]

• Cell proliferation-inducing gene 2 protein
• CKTSF1B1gremlin 1, cysteine knot superfamily, homolog
• Cysteine knot superfamily 1, BMP antagonist 1gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
• DAN domain family member 2
• DAND2
• DAND2GREMLIN
• Down-regulated in Mos-transformed cells protein
• DRM
• DRMMGC126660
• GREM1
• gremlin 1
• gremlin 1-like protein
• Gremlin
• gremlin-1
• IHG-2
• Increased in high glucose protein 2
• increased in high glucose-2
• proliferation-inducing gene 2

Background

In Xenopus, Gremlin belongs to a novel gene family that act as BMP antagonists in embryonic explants. The human homolog of Drm/Gremlin (CKTFS1B1) is localized on human chromosome 15q13--> q15. DRM-specific mRNA is expressed in different human tissues, including brain, ovary, intestine and colon. It has been suggested that down-regulation of DRM is associated with tumor progression, and support the hypothesis that human DRM may play an important role during both neuroembryological development and carcinogenesis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GREM1