GRAP2 Antibody [Alexa Fluor® 350]

• Reactivity: Hu, Mu
• Applications: WB
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Alexa Fluor 350

GRAP2 Antibody [Alexa Fluor® 350] Summary

• Immunogen: E. coli-derived recombinant human GRAP2
  Met1-Arg330
  Accession # O75791
• Specificity: Detects endogenous human and mouse GRAP2 in Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for GRAP2 Antibody [Alexa Fluor® 350]

• Adapter protein GRID
• GADS
• GADSSH3-SH2-SH3 adapter Mona
• GRAP2
• GRB2L
• GRB-2-like protein
• GRB2-related adapter protein 2
• GRB2-related adaptor protein 2
• GRB2-related protein with insert domain
• GRBLG
• GRBLGGRAP-2
• GRBX
• Grf40 adapter protein
• Grf40
• grf-40
• GRID
• GRIDGRPL
• Growth factor receptor-binding protein
• growth factor receptor-bound protein 2-related adaptor protein 2
• GRPL
• Hematopoietic cell-associated adapter protein GrpL
• hematopoietic cell-associated adaptor protein GRPL
• Mona
• P38
• Protein GADS
• SH3-SH2-SH3 adaptor molecule

Background

GRAP2 (GRB2 related adaptor protein 2), a divergent member of the GRB2/Sem5/Drk family, is an adaptor protein involved in leukocyte-specific protein-tyrosine kinase signaling. GRAP2 shares similar structural organization as GRB2 and GRAP with a central SH2 domain flanked by 2 SH3 domains. However, unlike GRB2 and GRAP, the SH2 domain and the C-terminal SH3 domain of GRAP2 contains a unique 120 amino acid glutamine/proline rich sequence. In T lymphocytes, GRAP2 interacts with LAT and SLP-76 to regulate NF-AT (nuclear factor of activated T cells) and form a signaling complex with HPK1 to mediate the JNK signaling pathway. GRAP2 also interacts with M-CSFR and the activated T cell co-stimulatory receptor CD28.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.