GPR39 Antibody [DyLight 488]

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Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
DyLight 488

GPR39 Antibody [DyLight 488] Summary

Immunogen
A synthetic peptide made to an internal region of the human GPR39 protein (within residues 400-500). [Swiss-Prot O43194]
Localization
Cell membrane; Multi-pass membrane protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GPR39
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:50
  • Immunohistochemistry-Paraffin 1:50
Application Notes
This GPR39 antibody is useful for Immunohistochemistry paraffin embedded sections. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.

Reactivity Notes

Human.Mouse reactivity reported in scientific literature (PMID: 25604641)

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for GPR39 Antibody [DyLight 488]

  • G protein-coupled receptor 39
  • GPR39
  • G-protein coupled receptor 39
  • MGC149541

Background

G protein-coupled receptor 39 is an important receptor in the Ghrelin family pathway, and plays an important role in hypertension and adipogenesis. When obestatin binds GPR39, vasodilation occurs in the heart and pancreas, as an effect of pituitary growth hormone effects there. This reaction seems to be protective in these tissues and decreases the effects of diabetes and hypercholesterolemia. However, overexpression of GPR39 is implicated in the formation of squamous cell carcinoma in the esophagus. In this cancer, metastases have inordinately high levels of GPR39.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol GPR39
Entrez