Glucagon Antibody

Product Discontinued

Glucagon Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 61-110 of Human GCG.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: GCG
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Glucagon Antibody

• GCG
• glicentin-related polypeptide
• GLP1
• GLP-1
• Glucagon
• glucagon-like peptide 1
• glucagon-like peptide 2
• GRPP

Background

Glucagon is a pancreatic hormone that functions as an antagonist to insulin, stimulating the conversion of glycogen to glucose and increasing blood sugar levels. Glucagon-like peptide-1 (GLP-1), Glucagon-like peptide-2 (GLP-2), VIP (vasoactive intestinal peptide) and PACAP (pituitary adenylate cyclase activating polypeptide) are members of the glucagon family of hormones. GLP-1 functions as a transmitter in the central nervous system, inhibiting feeding and drinking behavior, whereas GLP-2 is a stimulator of intestinal epithelial growth. VIP causes vasodilation resulting in the lowering of blood pressure. PACAP is abundant in the hypothalamus and has been shown to increase the synthesis of several hormones, including growth hormone.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Glucagon Antibody (NB100-91782)(3)

Publications using NB100-91782

• De Paoli M, Wood DW, Bohn MK et al. Investigating the protective effects of estrogen on beta cell health and the progression of hyperglycemia-induced atherosclerosis American journal of physiology. Endocrinology and metabolism 2022-07-13 [PMID: 35830687]
• Brown ML, Andrzejewski D, Burnside A et al. Activin Enhances alpha- to B-cell Transdifferentiation As A Source For B-Cells In Male FSTL3 Knockout Mice. Endocrinology. 2016-01-04 [PMID: 26727106] (IHC-P, Mouse)
• Rovira M, Scott SG, Liss AS et al. Rovira M, Scott SG, Liss AS, et al. Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. [PMID: 20018761] (ICC/IF, IHC-Fr, Mouse)

Bioinformatics

• Gene Symbol: GCG
• Entrez:
  • 2641(Human)
  • 24952(Rat)
• Uniprot:
  • P01275()
  • P06883(Rat)