GLP-1R Antibody (7H7) - BSA Free

ELISA: GLP-1R Antibody (7H7) [NBP3-26551] - The Binding Activity of GLP-1R with GLP-1R Antibody. Activity: Measured by its binding ability in a functional ELISA. Immobilized Human GLP-1R at 2 ug/mL can bind GLP-1R Antibody, the EC50 is 54.54-94.23 ng/mL.

Flow Cytometry: Human GLP-1R mAb (7H7) [NBP3-26551] - Untransfected HEK-293T cells surface (green line) and transfected Human GLP1R HEK-293T stable cells surface (red line) were stained with anti-GLP1R antibody (2µg/1*106cells), washed and then followed by FITC-conjugated anti-Human IgG Fc antibody and analyzed with flow cytometry.

• Reactivity: Hu
• Applications: ELISA, Flow
• Clone: 7H7
• Clonality: Monoclonal
• Host: Human
• Conjugate: Unconjugated
• Format: BSA Free

GLP-1R Antibody (7H7) - BSA Free Summary

• Description: Novus Biologicals Human GLP-1R Antibody (7H7) - BSA Free (NBP3-26551) is a recombinant monoclonal antibody validated for use in ELISA and Flow. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Additional Information: Recombinant monoclonal antibody expressed in HEK293F cells
• Immunogen: Recombinant Human GLP-1R protein [UniProt P43220]
• Source: HEK293
• Isotype: IgG4
• Clonality: Monoclonal
• Host: Human
• Gene: GLP1R
• Purity: Affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Flow Cytometry 1:20-1:200

Packaging, Storage & Formulations

• Storage: Store at -20 to -70C. Avoid freeze-thaw cycles.
• Buffer: 50% Glycerol, 0.01M PBS, PH 7.4
• Preservative: 0.03% Proclin 300
• Purity: Affinity purified

Alternate Names for GLP-1R Antibody (7H7) - BSA Free

• GLP-1 receptor
• GLP1R
• GLP-1R
• GLP-1-R
• glucagon-like peptide 1 receptor
• MGC138331

Background

GLP1R, a Glucagon Receptor, has been suggested to affect the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. Glucagon-like peptide 1 is an incretin hormone produced by enteroendocrine L-cells in the intestinal mucosa. The hormone is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Stimulation of the GLP-1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. These mechanisms include receptor-mediated enhancement of glucose-induced insulin secretion from pancreatic -cells, inhibition of gastric emptying with a delay in the gastrointestinal resorption of nutrients, inhibition of glucagon secretion, and inhibition of food intake. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). GLP1R knockout mice are viable, develop normally, but exhibit increased levels of blood glucose following oral glucose challenge in association with diminished levels of circulating insulin. Recently it has been shown that overexpression of glucagon-like peptide-1 receptor improves learning in rats (During et al. 2003). GLP1R has been reported in pancreas, brain, heart, kidney, lung, and stomach. ESTs have been isolated from kidney and skin libraries.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: GLP1R